Quantitative Automated Lesion Detection of Traumatic Brain Injury

NCT01022307 | Completed Results

• 1 other identifier: B6120-R
• Study Type: observational
• Target: 212
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators propose to develop quantitative automated lesion detection (QALD) procedures to identify brain damage following traumatic brain injury more accurately than is possible with a normal magnetic resonance imaging (MRI) scans. These procedures require about 1 hour of imaging in an MRI scanner. Subjects will also undergo about 2 hours of cognitive tests. The investigators will compare the results of the cognitive tests with those from MRI scanning to determine what brain regions are responsible for superior performance and for performance decrements.

Conditions

Traumatic Brain Injury

Keywords

behavioral data acquisition; MRI

Outcome Measures

Primary Outcomes (1)

• Performance on Trail-making Test, Part B

  z-score based on response time, regressed for age and computer use

  Single session generally several years after TBI depending on time of recruitment of subjects.

Study Arms (2)

Group 1: no history of TBI

184 participants with no history of traumatic brain injury (TBI).

Group 2: with a history of TBI

28 patients with a history of TBI. Most of these patients had suffered mild TBI.

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Our targeted population is veterans from OEF/OIF. Other subjects will be recruited as needed to fulfill recruitment targets.

You may qualify if:

• Control subjects from 18-50.
• Patients from 18-50 who have suffered TBI.

You may not qualify if:

• Substance abuse.
• Irremedial sensory deficits (blindness, deafness).
• Primary psychiatric disorder.
• Neurological disease unrelated to TBI.

Sponsors & Collaborators

• VA Office of Research and Development: lead

Study Sites (1)

VA Northern California HCS

Martinez, California, 94553, United States

Location

Related Publications (18)

• Alho K, Rinne T, Herron TJ, Woods DL. Stimulus-dependent activations and attention-related modulations in the auditory cortex: a meta-analysis of fMRI studies. Hear Res. 2014 Jan;307:29-41. doi: 10.1016/j.heares.2013.08.001. Epub 2013 Aug 11.

  PMID: 23938208 BACKGROUND

• Kang X, Herron TJ, Woods DL. Validation of the anisotropy index ellipsoidal area ratio in diffusion tensor imaging. Magn Reson Imaging. 2010 May;28(4):546-56. doi: 10.1016/j.mri.2009.12.015. Epub 2010 Jan 21.

  PMID: 20096529 BACKGROUND

• Woods DL, Herron TJ, Cate AD, Yund EW, Stecker GC, Rinne T, Kang X. Functional properties of human auditory cortical fields. Front Syst Neurosci. 2010 Dec 3;4:155. doi: 10.3389/fnsys.2010.00155. eCollection 2010.

  PMID: 21160558 BACKGROUND

• Cate AD, Herron TJ, Kang X, Yund EW, Woods DL. Intermodal attention modulates visual processing in dorsal and ventral streams. Neuroimage. 2012 Nov 15;63(3):1295-304. doi: 10.1016/j.neuroimage.2012.08.026. Epub 2012 Aug 16.

  PMID: 22917986 BACKGROUND

• Woods DL, Herron TJ, Cate AD, Kang X, Yund EW. Phonological processing in human auditory cortical fields. Front Hum Neurosci. 2011 Apr 20;5:42. doi: 10.3389/fnhum.2011.00042. eCollection 2011.

  PMID: 21541252 BACKGROUND

• Woods DL, Yund EW, Wyma JM, Ruff R, Herron TJ. Measuring executive function in control subjects and TBI patients with question completion time (QCT). Front Hum Neurosci. 2015 May 19;9:288. doi: 10.3389/fnhum.2015.00288. eCollection 2015.

  PMID: 26042021 BACKGROUND

• Woods DL, Wyma JM, Herron TJ, Yund EW. An improved spatial span test of visuospatial memory. Memory. 2016 Sep;24(8):1142-55. doi: 10.1080/09658211.2015.1076849. Epub 2015 Sep 11.

  PMID: 26357906 BACKGROUND

• Turken AU, Herron TJ, Kang X, O'Connor LE, Sorenson DJ, Baldo JV, Woods DL. Multimodal surface-based morphometry reveals diffuse cortical atrophy in traumatic brain injury. BMC Med Imaging. 2009 Dec 31;9:20. doi: 10.1186/1471-2342-9-20.

  PMID: 20043859 RESULT

• Kang X, Herron TJ, Cate AD, Yund EW, Woods DL. Hemispherically-unified surface maps of human cerebral cortex: reliability and hemispheric asymmetries. PLoS One. 2012;7(9):e45582. doi: 10.1371/journal.pone.0045582. Epub 2012 Sep 18.

  PMID: 23029115 RESULT

• Herron TJ, Kang X, Woods DL. Automated measurement of the human corpus callosum using MRI. Front Neuroinform. 2012 Sep 12;6:25. doi: 10.3389/fninf.2012.00025. eCollection 2012.

  PMID: 22988433 RESULT

• Kang X, Herron TJ, Turken AU, Woods DL. Diffusion properties of cortical and pericortical tissue: regional variations, reliability and methodological issues. Magn Reson Imaging. 2012 Oct;30(8):1111-22. doi: 10.1016/j.mri.2012.04.004. Epub 2012 Jun 12.

  PMID: 22698767 RESULT

• Kang X, Herron TJ, Woods DL. Regional variation, hemispheric asymmetries and gender differences in pericortical white matter. Neuroimage. 2011 Jun 15;56(4):2011-23. doi: 10.1016/j.neuroimage.2011.03.016. Epub 2011 Mar 22.

  PMID: 21397700 RESULT

• Whitaker KJ, Kang X, Herron TJ, Woods DL, Robertson LC, Alvarez BD. White matter microstructure throughout the brain correlates with visual imagery in grapheme-color synesthesia. Neuroimage. 2014 Apr 15;90:52-9. doi: 10.1016/j.neuroimage.2013.12.054. Epub 2014 Jan 7.

  PMID: 24406309 RESULT

• Zhang S, Cate AD, Herron TJ, Kang X, Yund EW, Bao S, Woods DL. Functional and anatomical properties of human visual cortical fields. Vision Res. 2015 Apr;109(Pt A):107-21. doi: 10.1016/j.visres.2015.01.015. Epub 2015 Feb 4.

  PMID: 25661165 RESULT

• Kang X, Herron TJ, Ettlinger M, Woods DL. Hemispheric asymmetries in cortical and subcortical anatomy. Laterality. 2015;20(6):658-84. doi: 10.1080/1357650X.2015.1032975. Epub 2015 Apr 20.

  PMID: 25894493 RESULT

• Woods DL, Wyma JM, Herron TJ, Yund EW. The Effects of Aging, Malingering, and Traumatic Brain Injury on Computerized Trail-Making Test Performance. PLoS One. 2015 Jun 10;10(6):e0124345. doi: 10.1371/journal.pone.0124345. eCollection 2015.

  PMID: 26060999 RESULT

• Woods DL, Wyma JM, Yund EW, Herron TJ, Reed B. Age-related slowing of response selection and production in a visual choice reaction time task. Front Hum Neurosci. 2015 Apr 23;9:193. doi: 10.3389/fnhum.2015.00193. eCollection 2015.

  PMID: 25954175 RESULT

• Woods DL, Wyma JM, Yund EW, Herron TJ, Reed B. Factors influencing the latency of simple reaction time. Front Hum Neurosci. 2015 Mar 26;9:131. doi: 10.3389/fnhum.2015.00131. eCollection 2015.

  PMID: 25859198 RESULT

Biospecimen

Retention: NONE RETAINED

No biospecimen, only digital data.

MeSH Terms

Conditions

Brain Injuries, Traumatic

Condition Hierarchy (Ancestors)

Brain Injuries; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries

Results Point of Contact

• Title: David L. Woods, Chief Clinical Neurophysiology
• Organization: VANCHCS

David.Woods@va.gob

925-372-2571

Study Officials

• David L. Woods, PhD

  VA Northern California HCS

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: FED
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 8, 2009
• First Posted: December 1, 2009
• Study Start: May 1, 2009
• Primary Completion: October 1, 2014
• Study Completion: October 1, 2014
• Last Updated: January 14, 2016
• Results First Posted: January 14, 2016

Record last verified: 2015-12

Locations

US (1)