Evaluation of Outcome Measures for Patients Diagnosed With Traumatic Brain Injury

NCT01020318 | Completed

• 2 other identifiers: 10000610-CC-0006
• Study Type: observational
• Target: 9
• Locations: 1 country
• Sites: 1

Brief Summary

Background:

• Traumatic brain injury (TBI) is a significant injury in the Armed Forces, but it is also common in the general population. This condition poses significant challenges for both diagnosis and therapy. However, the biological and neurological reasons for TBI remain poorly understood and are in need of more in-depth study.
• The National Institutes of Health is collaborating with several military medical centers and research units in a multi-year study of TBI in civilian and military patients. In anticipation of these research projects, the Clinical Center s Rehabilitation Medicine Department needs to become familiar with the instruments they will likely need to evaluate this group of subjects. Objectives:
• To evaluate potential test instruments in patients with TBI.
• To evaluate patient tolerance of an extensive battery of assessments and the time required to complete the assessments.
• To improve staff competencies on new or novel assessments of the TBI patient population Eligibility:
• Individuals 18 years of age and older who have been diagnosed with a traumatic brain injury in the past 5 years.
• Healthy volunteers 18 years of age and older who have had no instances of significant head trauma. Design:
• This study requires approximately 3 days of outpatient or inpatient evaluation.
• Subjects will undergo cognitive and neuropsychological tests, physical assessments, speech and language evaluation, and balance testing. Tests will be given orally, in writing, and on computers. The testing will be done in blocks of 2 to 3 hours, with rest periods as needed.
• Subjects may undergo any or all of the following assessments and screening tools, as determined by the researchers:
• Cognitive, quality of life, and functional assessments
• Speech, language, and swallowing assessments
• Physical functional performance and environment assessments (including balance testing)
• Subjects will remain under the care of their own health care providers while participating in this study.

Conditions

Traumatic Brain Injury

Keywords

Traumatic Brain Injury; TBI; Brain Injuries

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• For TBI patients: a diagnosis of TBI within the last 5 years
• For Healthy volunteers: no episode of head trauma resulting in an alteration in level of consciousness or loss of memory for the event.

You may not qualify if:

• For both study populations:
• Age less than 18 years
• Inability to speak or understand English well enough to complete study instruments
• Medically unstable on evaluation by an RMD physician, including those with clinically significant medical conditions that would make the research evaluations unsafe, logistically difficult or impossible to complete.
• Unable to provide informed consent.

Sponsors & Collaborators

• National Institutes of Health Clinical Center (CC): lead
• United States Department of Defense: collaborator
• Center for Neuroscience and Regenerative Medicine (CNRM): collaborator

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

MeSH Terms

Conditions

Brain Injuries, Traumatic; Brain Injuries

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries

Study Officials

• Leighton Chan, M.D.

  National Institutes of Health Clinical Center (CC)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH

Study Record Dates

• First Submitted: November 24, 2009
• First Posted: November 25, 2009
• Study Start: October 16, 2009
• Study Completion: May 16, 2014
• Last Updated: October 6, 2017

Record last verified: 2014-05-16

Locations

US (1)