Simvastatin in Patients With Isolated Arterial Hypertension

NCT01017835 | Unknown

• 1 other identifier: 503-5139-2
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to determine whether combined therapy with simvastatin and hypotensive drugs (ACEI or ARB) may decrease the blood pressure. Moreover, we would like to assess the influence of isolated hypertension on endothelial injury, and on the development of atherosclerosis.

Conditions

Hypertension

Keywords

statins; isolated hypertension; atherosclerosis; lipid profile

Study Arms (2)

statin treatment, isolated hypertension

treatment with statins, patients with isolated hypertension, with no hyperlipidemia, no diabetes, no smoking

placebo treatment, isolated hypertension

treatment with placebo, patients with isolated hypertension, with no hyperlipidemia, no diabetes, no smoking

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients hospitalized in the Department of Nephrology, Hypertension and Family Medicine,Clinical Hospital of Medical University of Lodz

You may qualify if:

• isolated hypertension (I or II class according to ESH guidelines 2009)

You may not qualify if:

• ischemic heart disease, prior percutaneous coronary intervention (PCI), prior coronary artery bypass grafting (CABG), heart failure, diabetes, hyperlipidemia, active smokers

Sponsors & Collaborators

• Medical University of Lodz: lead

Study Sites (1)

Departament of Nephrology, Hypertension and Family Medicine, Clinical Hospital of Medical University of Lodz

Lodz, 90-549, Poland

RECRUITING

Related Publications (3)

• Stepien M, Banach M, Mikhailidis DP, Gluba A, Kjeldsen SE, Rysz J. Role and significance of statins in the treatment of hypertensive patients. Curr Med Res Opin. 2009 Aug;25(8):1995-2005. doi: 10.1185/03007990903098081.

  PMID: 19555312 BACKGROUND

• Rysz J, Aronow WS, Stolarek RS, Hannam S, Mikhailidis DP, Banach M. Nephroprotective and clinical potential of statins in dialyzed patients. Expert Opin Ther Targets. 2009 May;13(5):541-50. doi: 10.1517/14728220902882130.

  PMID: 19368496 BACKGROUND

• Szadkowska I, Stanczyk A, Aronow WS, Kowalski J, Pawlicki L, Ahmed A, Banach M. Statin therapy in the elderly: a review. Arch Gerontol Geriatr. 2010 Jan-Feb;50(1):114-8. doi: 10.1016/j.archger.2008.12.012. Epub 2009 Feb 13.

  PMID: 19217673 BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

plasma

MeSH Terms

Conditions

Hypertension; Atherosclerosis

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases

Study Officials

• Maciej Banach, MD PhD

  Departament of Hypertension , Medical University of Lodz

  STUDY CHAIR

Central Study Contacts

Marta Michalska, MSc

CONTACT

501154853; michalska_marta84@wp.pl

Maciej Banach, MD PhD

CONTACT

604593040; maciejbanach@aol.co.uk

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: November 20, 2009
• First Posted: November 23, 2009
• Study Start: November 1, 2009
• Primary Completion: June 1, 2011
• Study Completion: January 1, 2012
• Last Updated: November 23, 2009

Record last verified: 2009-11

Locations

PL (1)