The Cognitive and Cerebral Blood Flow Effects of Resveratrol

NCT01010009 | Completed Results

• 1 other identifier: 22P2
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

Research shows that resveratrol is able to induce vasodilation (and therefore blood flow) by interacting with nitric oxide (NO). Research also shows that acute administration of metabolic substrates, like oxygen and glucose, can enhance aspects of cognitive performance in young, healthy humans. The aim of this investigation was to determine if the consumption of resveratrol could modulate cerebral blood flow and if this in turn could influence cognitive performance by increasing access to blood borne metabolic fuel. Results showed that compared to placebo, after consuming 500mg pure trans-resveratrol, levels of total haemoglobin were significantly higher in the frontal cortex of young, healthy participants during cognitive task completion. Cognitive performance was not effected.

Conditions

Cognitive and Cerebral Blood Flow Effects of Resveratrol

Keywords

resveratrol; cerebral blood flow; NIRS; cognitive performance

Outcome Measures

Primary Outcomes (2)

• Modulation of Levels of Total Haemoglobin

  This outcome measure provides the change from baseline values (in µmol/L) of total levels of haemoglobin during the 46-81 min post dose testing period. This was measured in the frontal cortex by near infrared spectroscopy (NIRS).

  0-81 mins (absorption period=1- 45 mins , post dose period 46- 81 mins)

• Modulation of Deoxygenated Levels of Haemoglobin

  This outcome measure provides the change from baseline values (in µmol/L) of levels of deoxygenated haemoglobin during the 46-81 min post dose testing period. This was measured in the frontal cortex by near infrared spectroscopy (NIRS).

  0-81 mins (absorption period=1- 45 mins , post dose period 46- 81 mins)

Secondary Outcomes (1)

• Number of Participants With Significant Modulation of Cognitive Performance

  46-81 mins post dose

Study Arms (3)

Resveratrol 250mg

EXPERIMENTAL

Dietary Supplement: Trans- resveratrol; Other: Placebo (silica)

Resveratrol 500mg

EXPERIMENTAL

Dietary Supplement: Trans- resveratrol; Other: Placebo (silica)

Placebo

PLACEBO COMPARATOR

Dietary Supplement: Trans- resveratrol; Other: Placebo (silica)

Interventions

Trans- resveratrol DIETARY_SUPPLEMENT

All 24 participants who completed the study took part in 3 conditions; receiving either 250mg resveratrol, 500mg resveratrol or placebo on separate days (with a 48hr-14day wash out period between each treatment) with the order dictated by a latin square. Treatment was administered in capsule form and in a double blind manner.

Also known as: Transmax from Biotivia.

Placebo; Resveratrol 250mg; Resveratrol 500mg

Placebo (silica) OTHER

All 24 participants who completed the study took part in 3 conditions; receiving either 250mg resveratrol, 500mg resveratrol or placebo on separate days (with a 48hr-14day wash out period between each treatment) with the order dictated by a latin square. Treatment was administered in capsule form and in a double blind manner.

Also known as: Pharmaceutical grade silica

Placebo; Resveratrol 250mg; Resveratrol 500mg

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male/female,
• Healthy
• Age 18-35 years old
• Non smoker
• Proficient in English
• Not taking any herbal or prescription medications
• Not pregnant
• Does not drink more than 6 cups of coffee per day

You may not qualify if:

• Suffered a head injury, neurological disorder or neuro-developmental disorder
• Food allergies/intolerances

Sponsors & Collaborators

• Northumbria University: lead

Study Sites (1)

Northumbria University

Newcastle upon Tyne, NE1 8ST, United Kingdom

Location

MeSH Terms

Interventions

Resveratrol; Silicon Dioxide

Intervention Hierarchy (Ancestors)

Stilbestrols; Stilbenes; Benzylidene Compounds; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons; Organic Chemicals; Polyphenols; Phenols; Minerals; Inorganic Chemicals; Oxides; Oxygen Compounds; Silicon Compounds

Results Point of Contact

• Title: Emma Wightman
• Organization: Northumbria university

emma.l.wightman@unn.ac.uk

+44 (0) 191 2437253

Study Officials

• Crystal Haskell

  Northumbria University

  STUDY DIRECTOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: November 6, 2009
• First Posted: November 9, 2009
• Study Start: June 1, 2008
• Primary Completion: March 1, 2009
• Study Completion: March 1, 2009
• Last Updated: May 23, 2012
• Results First Posted: April 18, 2011

Record last verified: 2012-05

Locations

GB (1)