NCT01005446

Brief Summary

The purpose of this study is to evaluate the use and efficacy of the Reverse® Shoulder Prosthesis for treatment of rotator cuff deficiency in subjects who are candidates for a total shoulder replacement (primary and revision subjects).

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
245

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Dec 2009

Longer than P75 for all trials

Geographic Reach
1 country

10 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

October 30, 2009

Completed
3 days until next milestone

First Posted

Study publicly available on registry

November 2, 2009

Completed
29 days until next milestone

Study Start

First participant enrolled

December 1, 2009

Completed
7.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2017

Completed
10 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2018

Completed
Last Updated

March 30, 2021

Status Verified

March 1, 2021

Enrollment Period

7.7 years

First QC Date

October 30, 2009

Last Update Submit

March 26, 2021

Conditions

Outcome Measures

Primary Outcomes (1)

  • Improvement in American Shoulder and Elbow Surgeons Score (ASES) from Baseline

    Improvement in American Shoulder and Elbow Surgeons Score (ASES) from Baseline. Assessments include: 1) Pain score where 0=no pain at all and 10=pain as bad as it can be 2) Function score where 0=my should is useless and 10=my shoulder is normal 3) Activity score where 0=unable to do and 3=Normal.

    2 year

Secondary Outcomes (5)

  • Radiologic Success

    5 year

  • Change in ASES score from Baseline

    5 year

  • SF36- (Short Form 36)Health Survey

    5 year

  • Change in Simple Shoulder Test from Baseline

    5 year

  • Subject Satisfaction Survey

    5 year

Study Arms (1)

RSP Device

Post Market Study

Device: Encore Reverse Shoulder Prosthesis (RSP®)

Interventions

The RSP is indicated for use in subjects with grossly rotator cuff deficient shoulder joints with severe arthropathy or a previously failed joint replacement with a grossly rotator cuff deficient shoulder joint.

Also known as: RSP®
RSP Device

Eligibility Criteria

Age60 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Subjects who are 60 years of age or older at the time of consent and are suffering from a grossly rotator cuff deficient shoulder joints with severe arthropathy or have a previously failed joint replacement with a grossly rotator cuff deficient shoulder joint.

You may qualify if:

  • Subject must be a candidate for a total shoulder joint replacement
  • Subject must be diagnosed with one or more of the following conditions:
  • Irreparable rotator cuff tear with gleno-humeral arthritis; Failed rotator cuff surgery with gleno-humeral instability or antero- superior escape; Failed shoulder replacement surgery
  • Subject has a functional deltoid muscle
  • Subject's joint must be anatomically and functionally suited to receive the selected implant
  • Subject is 60 years of age or older (≥ 60 yrs of age) at time of consent
  • Subject is likely to be available for all study visits
  • Subject is able and willing to sign the informed consent and follow study procedures
  • Subject is not pregnant

You may not qualify if:

  • Subject has a non-functional deltoid muscle
  • Subject has a mental condition(s) that may interfere with the subject's ability to give an informed consent or willingness to fulfill the study requirements (i.e., severe mental retardation such that the Subject cannot understand the informed consent process, global dementia, prior strokes that interfere with the Subject's cognitive abilities, senile dementia, and Alzheimer's Disease)
  • Subject is a prisoner
  • Subject has high levels of physical activity (ex. competitive sports, heavy physical labor)
  • Subject is pregnant
  • Subject has an active infection or sepsis
  • Subject has loss of ligamentous structures
  • Subject has a history of alcoholism or other addictions (current or past)
  • Subject has muscular, neurological or vascular deficiencies which compromise the affected extremity (i.e., Parkinson's Disease, Syringomyelia and Multiple Sclerosis, Charcot joints)
  • Subject has severe glenoid bone loss
  • Subject has known materials sensitivity (to metals)
  • Subject is younger than 60 years of age (\< 60 years of age) at consent

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (10)

Stanford University - Dept. of Orthopedics

Redwood City, California, 94063, United States

Location

Coastal Orthopedics & Sports Medicine

Bradenton, Florida, 34209, United States

Location

Orthopaedic Institute at Holy Cross Hospital

Fort Lauderdale, Florida, 33334, United States

Location

Rush-Presbyterian-St. Luke's Medical Center

Chicago, Illinois, 60612, United States

Location

Norton Orthopaedic & Sports Medicine Specialists

Louisville, Kentucky, 40241, United States

Location

Excelsior Orthopaedics

Amherst, New York, 14226, United States

Location

Cincinnati Sports Medicine and Orthopeadic Center

Cincinnati, Ohio, 45242, United States

Location

Geisinger Medical Center

Danville, Pennsylvania, 17822, United States

Location

Texas Center for Joint Replacement

Plano, Texas, 75093, United States

Location

Rimrock Orthopedics

St. George, Utah, 84790, United States

Location

Related Links

Study Officials

  • Samer S. Hasan, M.D.

    Cincinnati Sports Medicine and Orthopaedic Center

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 30, 2009

First Posted

November 2, 2009

Study Start

December 1, 2009

Primary Completion

August 1, 2017

Study Completion

June 1, 2018

Last Updated

March 30, 2021

Record last verified: 2021-03

Locations