Effects of Different Mode of Exercise Training on Type 2 Diabetes
Differential Effects of Aerobic Versus Progressive Resistance Training on Metabolic Profile and Fitness in Older Adults With Diabetes Mellitus - a Randomized Controlled Trial
1 other identifier
interventional
60
1 country
1
Brief Summary
Randomized study on the comparison between aerobic training versus progressive resistance training over a 2 months period for older adults with type 2 diabetes. The hypothesis is that progressive resistance training is just as effective as aerobic training on Hba1c and could be an alternative training for those older diabetic patients who cannot participate in aerobic exercise.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable diabetes-mellitus-type-2
Started Dec 2002
Longer than P75 for not_applicable diabetes-mellitus-type-2
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2002
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2006
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2006
CompletedFirst Submitted
Initial submission to the registry
October 20, 2009
CompletedFirst Posted
Study publicly available on registry
October 23, 2009
CompletedFebruary 10, 2017
February 1, 2017
3.5 years
October 20, 2009
February 8, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Hemoglobin A, Glycosylated (Hba1c). Measuring unit: percentage
Blood was drawn from each subject who fasted at least 10 hours overnight. Hba1c (%) was measured using high performance liquid chromatography (HPLC Variant II Bio Rad Laboratories, Munich, Germany). Change in Hba1c before and after intervention were looked at.
2 months
Secondary Outcomes (3)
Peak volume of oxygen consumed (VO2peak) or fitness level. Measuring unit: ml/kg/min
2 months
Anthropometric measurements
2 months
Cholesterol
2 months
Study Arms (2)
Aerobic Training
ACTIVE COMPARATOR50 minutes of aerobic training, 18 sessions within 2 months period
Progressive Resistance Training
EXPERIMENTAL50 minutes of progressive resistance training consisting of nine resistance exercises, each conducted 3 sets of 10 repetitions. 18 sessions over 2 months period.
Interventions
18 sessions over 2 months period. Each session consist of 50 minutes of aerobic training at 65-70 % of maximum predicted heart rate
18 sessions completed in 2 months. each session consists of 50 minutes of resistance training which is made up of 3 sets of 10 repetitions of nine resistive exercises using machines and free weights at 65-70% of 1-repetitive maximum.
Eligibility Criteria
You may qualify if:
- aged 50 years and above,
- Hba1c between 8 to 10 % in the past one month,
- sedentary,
- able to continuously walk for at least 20 minutes and climbed one flight of stairs unaided without stopping were eligible for participation.
You may not qualify if:
- uncontrolled diabetes mellitus with Hba1c more than 10% or if escalation of treatment of glycemic control or dyslipidemia was likely to be necessary over the 2 months training period period,
- congestive cardiac failure, unstable angina or acute myocardial infarction within the last one year,
- proliferative diabetic retinopathy,
- uncontrolled hypertension,
- advanced arthritis likely to limit mobility or participation in prescribed exercises,
- respiratory conditions such as asthma and chronic obstructive lung disease,
- significant proteinuria or chronic renal insufficiency,
- received drugs for the treatment of obesity or very low caloric diet (VLCD, less than 1000 kcal/ day),
- renal disease and
- inability to monitor glucose level or comply with exercise program.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Singapore General Hospital
Singapore, 169608, Singapore
Related Publications (4)
Boule NG, Haddad E, Kenny GP, Wells GA, Sigal RJ. Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials. JAMA. 2001 Sep 12;286(10):1218-27. doi: 10.1001/jama.286.10.1218.
PMID: 11559268BACKGROUNDArora E, Shenoy S, Sandhu JS. Effects of resistance training on metabolic profile of adults with type 2 diabetes. Indian J Med Res. 2009 May;129(5):515-9.
PMID: 19675378BACKGROUNDNg CL, Tai ES, Goh SY, Wee HL. Health status of older adults with Type 2 diabetes mellitus after aerobic or resistance training: a randomised trial. Health Qual Life Outcomes. 2011 Aug 2;9:59. doi: 10.1186/1477-7525-9-59.
PMID: 21810269DERIVEDNg CL, Goh SY, Malhotra R, Ostbye T, Tai ES. Minimal difference between aerobic and progressive resistance exercise on metabolic profile and fitness in older adults with diabetes mellitus: a randomised trial. J Physiother. 2010;56(3):163-70. doi: 10.1016/s1836-9553(10)70021-7.
PMID: 20795922DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Li Whye Cindy Ng
Singapore General Hospital
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 20, 2009
First Posted
October 23, 2009
Study Start
December 1, 2002
Primary Completion
June 1, 2006
Study Completion
June 1, 2006
Last Updated
February 10, 2017
Record last verified: 2017-02