An Exploration of Genetic Testing for Prostate Cancer Susceptibility
An Exploration of Factors Affecting Interest and Uptake of Genetic Testing for Prostate Cancer Susceptibility: The Clinical Application of Genetic Testing for Lower Risk Cancer Predisposition Genes
1 other identifier
observational
200
1 country
1
Brief Summary
Study of the factors that affect interest in - and uptake of - genetic testing for variants that predispose to prostate cancer from the perspective of the patient.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Aug 2009
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2009
CompletedFirst Submitted
Initial submission to the registry
October 16, 2009
CompletedFirst Posted
Study publicly available on registry
October 19, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2011
CompletedOctober 19, 2009
October 1, 2009
1.5 years
October 16, 2009
October 16, 2009
Conditions
Outcome Measures
Primary Outcomes (1)
Whether cancer worry changes between the two time-points (measured using the Impact of Event Scale)
Secondary Outcomes (4)
Why are men interested/ not interested in seeking genetic profiling for prostate cancer, and what might be the uptake of such testing?
What are the expectations of this testing from the perspective of the user, what are the perceived benefits and limitations of testing and how do these change through the testing process
Is there a relationship between a family history of cancer, cancer worry, and a persons intention to seek genetic testing?
How would the information provided by such a test be used by the individual and the family and how could this impact upon the healthcare system
Eligibility Criteria
Men with strong family history of prostate cancer.
You may qualify if:
- Men with a positive family history of prostate cancer. The definition of a positive family history will be: Men with a first degree relative with prostate cancer diagnosed at \<70 years; Men with two relatives with prostate cancer where at least on is diagnosed at \<70 years; Men with three relatives with prostate cancer diagnosed at any age
- Age 40-69 years
- No previous biopsy for raised PSA
- Absence of any psychological, familial, sociological or geographic situation potentially hampering compliance with the study protocol and follow-up schedule.
You may not qualify if:
- Previous prostate cancer
- Men from families where there is known to be a mutation in a high-risk prostate cancer gene
- Men who have had a prostate biopsy within the last 12 months.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Royal Marsden NHS Foundation Trust
Sutton, Surrey, SM2 5PT, United Kingdom
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Dr Rosalind Eeles
Institute of Cancer Research, United Kingdom
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
October 16, 2009
First Posted
October 19, 2009
Study Start
August 1, 2009
Primary Completion
February 1, 2011
Study Completion
February 1, 2011
Last Updated
October 19, 2009
Record last verified: 2009-10