Endoscopic Evaluation in Transplantation Candidates

NCT00990470 | Completed

• 1 other identifier: MHH-Endo-1009
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

In consideration of the limited supply of donor organs, the careful selection of transplant candidates is essential to optimize patient outcome after transplantation. Therefore an extensive evaluation of transplant candidates including among others esophagogastroduodenoscopy (EGD) and colonoscopy has been implemented in our centre. The data regarding the prevalence of upper and lower gastrointestinal (GI) pathology in transplant candidates are contradictory and are based on only a few retrospective studies, which often include only a subgroup of transplant candidates. The goal of this project is a prospective evaluation of the frequency of GI pathologies in transplant candidates with specific focus on the following questions:

1. 1.Are there GI-pathologies that occur at a higher prevalence in transplant candidates than described in the general population and is there an increase of GI-pathologies since the introduction of the urgency-based organ allocation leading to sicker transplant candidates?
2. 2.What is the influence of endoscopic findings on patient management before transplantation?
3. 3.Which risk factors can be identified that predict the presence of GI-lesions?
4. 4.Is there a subgroup of patients, in which screening colonoscopy before liver transplantation can not be recommended considering the cost/benefit ratio?
5. 5.Is there a correlation of endoscopic findings with outcome after liver transplantation or with gastrointestinal complications during or after transplantation (e.g. gastrointestinal bleeding, perforation or gastrointestinal malignancy)?

Conditions

Liver Transplantation

Keywords

Transplantation; Liver; Endoscopy; Colonoscopy; Gastroscopy

Eligibility Criteria

• Age: 1 Day - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients evaluated for Tranplantation at Hannover Medical School

You may qualify if:

• Patients who receive upper and/or lower endoscopy during evaluation for transplantation

You may not qualify if:

• patient already on waiting list

Sponsors & Collaborators

• Hannover Medical School: lead

Study Sites (1)

Hannover Medical School

Hanover, 30625, Germany

Location

Related Publications (1)

• Weismuller TJ, Bleich F, Negm AA, Schneider A, Lankisch TO, Manns MP, Strassburg CP, Wedemeyer J. Screening colonoscopy in liver transplant candidates: risks and findings. Clin Transplant. 2013 Mar-Apr;27(2):E161-8. doi: 10.1111/ctr.12083. Epub 2013 Feb 6.

  PMID: 23383749 DERIVED

Study Officials

• Jochen Wedemeyer, MD

  MHH

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr. T. Weismüller

Study Record Dates

• First Submitted: October 5, 2009
• First Posted: October 6, 2009
• Study Start: February 1, 2006
• Primary Completion: December 1, 2010
• Study Completion: December 1, 2010
• Last Updated: October 10, 2011

Record last verified: 2011-10

Locations

DE (1)