Brain and Cognitive Changes After Reasoning or Physical Training in Cognitively Normal Seniors

NCT00977418 | Completed DMC

• 2 other identifiers: 07-19NIH 1RC1AG035954-01
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Seniors 65 years of age and older represent one of the fastest growing segments of society with the population doubling within the next 25 years with dramatic rates of mental decline, costing society billions of dollars each year. The proposed research seeks to discover whether relatively short term mental or physical training can enhance gist reasoning, generalize to untrained cognitive areas and modify/strengthen brain function in areas susceptible to aging processes. To identify neuroprotective and non-pharmacological interventions to prevent mental decline and maximize cognitive brain health during the course of the adult lifespan has major public policy implications.

Conditions

Hearing Impaired

Keywords

Healthy Aging; Exercise; Cognition; Cognitive Training; Keeping healthy seniors as mentally efficient as possible

Outcome Measures

Primary Outcomes (1)

• Cognitive Scores

  begining (0 weeks), middle (6 weeks) and end (12 weeks) of study

Secondary Outcomes (1)

• MRI images

  begining (0 weeks), middle (6 weeks) and end (12 weeks) of study

Study Arms (2)

No intervention

NO INTERVENTION

Seniors undergo all testing but remain current lifestyle

Training

EXPERIMENTAL

Groups will undergo either physical or mental training. Physical training is 1 hour aerobic training 3 times per week for 12 weeks. Mental training is 1 hour Strategic Memory Advanced Reasoning Training 3 times per week.

Behavioral: SMART- Strategic Memory and Reasoning Training; Other: Physical Exercise

Interventions

SMART- Strategic Memory and Reasoning Training BEHAVIORAL

Teach people to filter out un necessary or unimportant details to enhance mental efficiency. This training will be done over 12 weeks for 3 hours each week.

Training

Physical Exercise OTHER

The group with undergo 1 hour of aerobic exercise (at 50-70 % of the participants max oxygen intake) 3 times a week for 12 weeks.

Training

Eligibility Criteria

• Age: 60 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• The study will include 60 cognitively normal seniors between the ages of 60 and 75 years.
• Participants will have normal IQ, be native speakers of English and have a minimum of high school education.

You may not qualify if:

• Participants with a previous history of stroke, diabetes, untreated hypertension, major surgeries within the past 6 months, major psychiatric disorder, depression or cognitive impairment will be excluded.
• Additionally, anyone that has a condition that would exclude them from MRI will not be included.

Sponsors & Collaborators

• The University of Texas at Dallas: lead
• National Institutes of Health (NIH): collaborator

Study Sites (1)

The University of Texas at Dallas

Dallas, Texas, 75235, United States

Location

Related Publications (1)

• Motes MA, Yezhuvath US, Aslan S, Spence JS, Rypma B, Chapman SB. Higher-order cognitive training effects on processing speed-related neural activity: a randomized trial. Neurobiol Aging. 2018 Feb;62:72-81. doi: 10.1016/j.neurobiolaging.2017.10.003. Epub 2017 Oct 12.

  PMID: 29121545 DERIVED

MeSH Terms

Conditions

Hearing Loss; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Hearing Disorders; Ear Diseases; Otorhinolaryngologic Diseases; Sensation Disorders; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Sandra Chapman, Ph.D.

  The University of Texas at Dallas

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 14, 2009
• First Posted: September 15, 2009
• Study Start: June 1, 2012
• Primary Completion: June 1, 2013
• Study Completion: September 1, 2013
• Last Updated: July 11, 2016

Record last verified: 2012-06

Locations

US (1)