The Swiss Venous Thromboembolism Cohort 65+
SWITCO65+
Swiss Venous Thromboembolism Cohort Study of Elderly Patients With Acute Venous Thromboembolism
1 other identifier
observational
1,003
1 country
9
Brief Summary
The purpose of this prospective multicenter cohort study is to examine long-term medical outcomes, quality of life, and medical resource utilization in elderly patients (\>= 65 years) with acute venous thromboembolism (i.e., acute pulmonary embolism and/or deep vein thrombosis)
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Sep 2009
Longer than P75 for all trials
9 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2009
CompletedFirst Submitted
Initial submission to the registry
September 8, 2009
CompletedFirst Posted
Study publicly available on registry
September 9, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2013
CompletedDecember 2, 2014
December 1, 2014
2.5 years
September 8, 2009
December 1, 2014
Conditions
Outcome Measures
Primary Outcomes (1)
Venous thromboembolism recurrence
3-48 months
Secondary Outcomes (5)
Overall mortality
3-48 months
Major bleeding
3-48 months
Post-thrombotic syndrome
3-48 months
Generic and disease-specific health-related quality of life
3-48 months
Medical resource utilization
3-48 months
Eligibility Criteria
Outpatients and inpatients with acute venous thromboembolism from 9 Swiss university and non-university hospitals
You may qualify if:
- Objectively confirmed acute pulmonary embolism and/or deep vein thrombosis
- Age \>=65 years
You may not qualify if:
- Thrombosis at a different site than lower limb
- Catheter-related thrombosis
- Insufficient spoken language ability in German or French
- Follow-up not possible (e.g., terminally ill patients)
- Informed consent not possible (e.g., severe dementia)
- Prior enrolment in the study
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (9)
Kantonsspital Baden
Baden, Switzerland
University Hospital of Basel
Basel, Switzerland
University Hospital of Bern
Bern, Switzerland
Kantonsspital Frauenfeld
Frauenfeld, Switzerland
University Hospital of Geneva
Geneva, Switzerland
University Hospital of Lausanne
Lausanne, Switzerland
Kantonsspital Luzern
Lucerne, Switzerland
Kantonsspital St. Gallen
Sankt Gallen, Switzerland
University Hospital of Zurich
Zurich, Switzerland
Related Publications (7)
Jaquet E, Tritschler T, Stalder O, Limacher A, Mean M, Rodondi N, Aujesky D. Prediction of short-term prognosis in elderly patients with acute pulmonary embolism: validation of the RIETE score. J Thromb Haemost. 2018 Jul;16(7):1313-1320. doi: 10.1111/jth.14137. Epub 2018 May 30.
PMID: 29733493DERIVEDLauber S, Limacher A, Tritschler T, Stalder O, Mean M, Righini M, Aschwanden M, Beer JH, Frauchiger B, Osterwalder J, Kucher N, Lammle B, Cornuz J, Angelillo-Scherrer A, Matter CM, Husmann M, Banyai M, Staub D, Mazzolai L, Hugli O, Rodondi N, Aujesky D. Predictors and Outcomes of Recurrent Venous Thromboembolism in Elderly Patients. Am J Med. 2018 Jun;131(6):703.e7-703.e16. doi: 10.1016/j.amjmed.2017.12.015. Epub 2018 Jan 4.
PMID: 29307536DERIVEDSeiler E, Limacher A, Mean M, Beer HJ, Osterwalder J, Frauchiger B, Righini M, Aschwanden M, Matter CM, Banyai M, Kucher N, Staub D, Lammle B, Rodondi N, Squizzato A, Aujesky D. Derivation and validation of a novel bleeding risk score for elderly patients with venous thromboembolism on extended anticoagulation. Thromb Haemost. 2017 Aug 24;117(10). doi: 10.1160/TH17-03-0162. Online ahead of print.
PMID: 28837210DERIVEDHofmann E, Limacher A, Mean M, Kucher N, Righini M, Frauchiger B, Beer JH, Osterwalder J, Aschwanden M, Matter CM, Banyai M, Egloff M, Hugli O, Staub D, Bounameaux H, Rodondi N, Aujesky D. Echocardiography does not predict mortality in hemodynamically stable elderly patients with acute pulmonary embolism. Thromb Res. 2016 Sep;145:67-71. doi: 10.1016/j.thromres.2016.07.014. Epub 2016 Jul 27.
PMID: 27498122DERIVEDVuilleumier N, Simona A, Mean M, Limacher A, Lescuyer P, Gerstel E, Bounameaux H, Aujesky D, Righini M. Comparison of Cardiac and Non-Cardiac Biomarkers for Risk Stratification in Elderly Patients with Non-Massive Pulmonary Embolism. PLoS One. 2016 May 24;11(5):e0155973. doi: 10.1371/journal.pone.0155973. eCollection 2016.
PMID: 27219621DERIVEDTritschler T, Mean M, Limacher A, Rodondi N, Aujesky D. Predicting recurrence after unprovoked venous thromboembolism: prospective validation of the updated Vienna Prediction Model. Blood. 2015 Oct 15;126(16):1949-51. doi: 10.1182/blood-2015-04-641225. Epub 2015 Sep 4.
PMID: 26341256DERIVEDFrey PM, Mean M, Limacher A, Jaeger K, Beer HJ, Frauchiger B, Aschwanden M, Rodondi N, Righini M, Egloff M, Osterwalder J, Kucher N, Angelillo-Scherrer A, Husmann M, Banyai M, Matter CM, Aujesky D. Physical activity and risk of bleeding in elderly patients taking anticoagulants. J Thromb Haemost. 2015 Feb;13(2):197-205. doi: 10.1111/jth.12793. Epub 2014 Dec 30.
PMID: 25403550DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Director of the Division of General Internal Medicine
Study Record Dates
First Submitted
September 8, 2009
First Posted
September 9, 2009
Study Start
September 1, 2009
Primary Completion
March 1, 2012
Study Completion
December 1, 2013
Last Updated
December 2, 2014
Record last verified: 2014-12