Smoking Cessation Effect of Tea Filter Through Inhibition of Nicotine Receptor

NCT00971529 | Completed DMC

• 1 other identifier: zhaotaoliang123
• Study Type: observational
• Target: 159
• Locations: 1 country
• Sites: 1

Brief Summary

Cigarette smoking is the major risk factor for a series of life threatening diseases including cancer and heart attack, which causes millions of deaths each year worldwide. Many of the harmful effects of cigarette smoking can be reversed by quitting; however, due to the addictive nature of nicotine, quitting smoking is extremely difficult. Despite the efforts, currently available methods produce only modest smoking cessation rates with relapse. Previously, tea components were shown to protect effect against cigarette smoke-induced toxicity. Here the investigator reported an unprecedented smoking cessation effect of tea. Green tea was made into cigarette filters and tested for its smoking cessation effect in a double-blind clinical study. The tea filter could effectively achieve abstinence relapse using smoking process to quite smoking and easy to be used by smoker without any side effects and psychological obstacles. This work provides a new idea and innovative method to combat tobacco epidemic. Its implementation and popularization may make a great contribution towards to reducing the smoking-related diseases, and relieving the public health burden and pollution caused by cigarette smoking.

Conditions

Tobacco Cessation

Keywords

Smoking cessation; tea filter

Outcome Measures

Primary Outcomes (1)

• number of cigarettes consumed daily by every volunteer smoker

  1-5 months

Secondary Outcomes (1)

• exhaled carbon monoxide by the volunteers

  in the evening

Study Arms (2)

lifestyle

70 volunteers were double-blinded, placebo-controlled and randomized into 2 groups (smoking with tea filters or regular filters).

tea filter

The investigators then recruited 59 volunteers with longer smoking history and stronger desire for quitting smoking for smoking cessation test using the tea filter.

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

70 volunteers were double-blinded, placebo-controlled and randomized into 2 groups (smoking with tea filters or regular filters). The investigators then recruited 59 volunteers with longer smoking history and stronger desire for quitting smoking for smoking cessation test using the tea filter.

You may qualify if:

• Healthy male cigarette smokers, aged 18 to 65 years

You may not qualify if:

• Major depression within the prior year
• Panic disorder
• Psychosis
• Bipolar disorder
• Use of nicotine replacement therapy or other drugs within the previous 3 months
• Cardiovascular disease
• Clinically significant medical disease
• Drug or alcohol abuse or dependence within the past year
• Use of tobacco products other than cigarette smoking within the previous month.

Sponsors & Collaborators

• General Hospital of Beijing PLA Military Region: lead
• Chinese Academy of Sciences: collaborator

Study Sites (1)

Ran Tao

Beijing, 100700, China

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

CO

MeSH Terms

Conditions

Tobacco Use Cessation; Smoking Cessation

Condition Hierarchy (Ancestors)

Health Behavior; Behavior

Study Officials

• Ran Tao, MD

  Addiction Branch, Beijing Military Reneral Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: August 20, 2009
• First Posted: September 3, 2009
• Study Start: January 1, 2009
• Primary Completion: May 1, 2009
• Study Completion: July 1, 2009
• Last Updated: September 4, 2009

Record last verified: 2009-09

Locations

CN (1)