Olfactory Dysfunction of Rhinosinusitis - Cyclic Adenosine Monophosphate (cAMP)/Calcium Signaling Study

NCT00970190 | Completed

• 1 other identifier: 36534-B
• Study Type: observational
• Target: 99
• Locations: 1 country
• Sites: 1

Brief Summary

The study examines the biochemistry underlying human olfaction in both normal and diseased states. The study aims are: 1. to determine the levels of cAMP in olfactory tissue from people with chronic rhinosinusitis and other nasal disorders. 2. to correlate preoperative olfactory function with cAMP levels from biopsied olfactory tissue. 3. to determine odorant and pheromone-mediated activation of cultured human olfactory sensory neurons using calcium imaging and 4. to determine odorant and pheromone-mediated activation of cultured human olfactory sensory neurons using "smell-chip" technology.

Conditions

Sinusitis

Keywords

sinusitis

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients presenting to the University of Washington Rhinology Clinic for evaluation of sinus problems

You may qualify if:

• Subjects will be 18 years old and over and scheduled for one of the following:
• endoscopic sinus surgery for chronic sinusitis
• endoscopic transnasal approach to the pituitary for pituitary tumor removal
• endoscopic inferior turbinectomy or septoplasty for nasal congestion
• endoscopic repair of cerebrospinal fluid (CSF) leaks

You may not qualify if:

• Subjects are excluded if they are unable to give informed consent or unable to complete self-administered questionnaires due to English language barrier, cognitive impairment, or severe medical conditions

Sponsors & Collaborators

• Greg Davis: lead

Study Sites (1)

University of Washington Medical Center

Seattle, Washington, 98195, United States

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Samples consist of discarded tissue resulting from the following clinical procedures: endoscopic sinus surgery for chronic sinusitis, endoscopic transnasal approach to the pituitary for pituitary tumor removal, endoscopic inferior turbinectomy or septoplasty for nasal congestion and endoscopic repair of CSF leaks. Samples will only be retained for 1 year post-surgery and then destroyed.

MeSH Terms

Conditions

Sinusitis

Condition Hierarchy (Ancestors)

Respiratory Tract Infections; Infections; Paranasal Sinus Diseases; Nose Diseases; Respiratory Tract Diseases; Otorhinolaryngologic Diseases

Study Officials

• Greg E Davis, MD, MPH

  University of Washington

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: August 31, 2009
• First Posted: September 2, 2009
• Study Start: August 1, 2009
• Primary Completion: April 1, 2014
• Study Completion: April 1, 2014
• Last Updated: December 11, 2014

Record last verified: 2014-12

Locations

US (1)