NCT00966134

Brief Summary

Regulation of ghrelin, growth hormone and growth factors at high altitude and their change during ascent to high altitude has not been studied in depth yet. The study includes 33 volunteers (12f) investigated at sea level, 4 days after ascent to 3440m and 14 days after ascent to 5400-5900m. The investigators hypothesized that during ascent growth hormone levels would increase to compensate for the higher energy needs at high altitude.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Apr 2002

Typical duration for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2002

Completed
3.4 years until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2005

Completed
4 years until next milestone

First Submitted

Initial submission to the registry

August 24, 2009

Completed
2 days until next milestone

First Posted

Study publicly available on registry

August 26, 2009

Completed
Last Updated

February 23, 2010

Status Verified

August 1, 2009

First QC Date

August 24, 2009

Last Update Submit

February 22, 2010

Conditions

HealthyGrowth Hormone

Keywords

mountain medicineghrelingrowth hormonehypoxiaphysiology of hormonal adaptation to high altitude

Outcome Measures

Primary Outcomes (1)

  • Ghrelin, growth hormone, insulin-like growth factor I (IGF-I), IGF binding protein 1 (IGFBP1), IGF binding protein 2 (IGFBP2), IGF binding protein 3 (IGFBP3), acid-labile subunit (ALS), insulin, prolactin

    14 days

Study Arms (1)

probands

Other: exposure to high altitude

Interventions

exposure to high altitudeOTHER
probands

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Healthy Caucasians from an Alpinist association

You may qualify if:

  • Healthy and good physical fitness

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Hypoxia

Condition Hierarchy (Ancestors)

Signs and Symptoms, RespiratorySigns and SymptomsPathological Conditions, Signs and Symptoms

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

August 24, 2009

First Posted

August 26, 2009

Study Start

April 1, 2002

Study Completion

September 1, 2005

Last Updated

February 23, 2010

Record last verified: 2009-08