The Renin-Aldosterone Axis in Postural Tachycardia Syndrome
2 other identifiers
interventional
28
1 country
1
Brief Summary
The purpose of this study is to determine the role of the renin-angiotensin-aldosterone in the pathophysiology of postural tachycardia syndrome, and to provide an insight about the disease process in this disorder.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for phase_1
Started Apr 2009
Typical duration for phase_1
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2009
CompletedFirst Submitted
Initial submission to the registry
August 18, 2009
CompletedFirst Posted
Study publicly available on registry
August 20, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2012
CompletedResults Posted
Study results publicly available
August 17, 2018
CompletedSeptember 16, 2025
September 1, 2025
3.7 years
August 18, 2009
November 16, 2017
September 3, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Mean Arterial Blood Pressure Change
Change in MAP from baseline to after 1h of infusion.
1 hour
Secondary Outcomes (3)
Plasma Renin Activity
1 hour
Aldosterone Level
1 hour
Cortisol Level
1 hour
Study Arms (2)
Control
EXPERIMENTALHealthy controls
Postural Tachycardia Syndrome
EXPERIMENTALPatients with Postural Tachycardia Syndrome
Interventions
Eligibility Criteria
You may qualify if:
- Diagnosis of postural tachycardia syndrome by the Vanderbilt Autonomic Dysfunction Center criteria
- Age between 18-64 years
- Male or females are eligible
- Able and willing to provide informed consent
- Healthy control subjects with no major medical problem (including postural tachycardia syndrome), free of medications during the study
You may not qualify if:
- Overt cause of postural tachycardia e.g., dehydration
- Inability to give or withdraw informed consent
- Pregnancy
- Hypertension (BP \> 140/90)
- Significant co-morbid condition
- Other factors which in the investigator's opinion would prevent the subject from completing the protocol
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Vanderbilt University
Nashville, Tennessee, 37232, United States
Related Publications (1)
Mustafa HI, Raj SR, Diedrich A, Black BK, Paranjape SY, Dupont WD, Williams GH, Biaggioni I, Robertson D. Altered systemic hemodynamic and baroreflex response to angiotensin II in postural tachycardia syndrome. Circ Arrhythm Electrophysiol. 2012 Feb;5(1):173-80. doi: 10.1161/CIRCEP.111.965343. Epub 2012 Jan 13.
PMID: 22247480DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Limitations and Caveats
This was a single center, acute study.
Results Point of Contact
- Title
- Hossam Mustafa
- Organization
- Vanderbilt University Medical Center
Publication Agreements
- PI is Sponsor Employee
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 1
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Adjunct Assoc Professor
Study Record Dates
First Submitted
August 18, 2009
First Posted
August 20, 2009
Study Start
April 1, 2009
Primary Completion
December 1, 2012
Study Completion
December 1, 2012
Last Updated
September 16, 2025
Results First Posted
August 17, 2018
Record last verified: 2025-09