Motor Development and Orthoses in Spinal Muscular Atrophy (SMA)

NCT00961103 | Completed DMC

• 1 other identifier: UDGEE-SMA
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Spinal Muscular Atrophy (SMA) is neurodegenerative disease of anterior horn cells of spinal cord and represents the second more frequent pathology in childhood. According to the age of onset and the maximum motor function the disorder is classified in 4 types. Patients with SMA II and SMA III often use orthoses to achieve postural and dynamic functions. In this retrospective observational study the investigators describe the characteristics of sitting position, standing and walking correlated to type and time of orthoses used.

Conditions

Spinal Muscular Atrophy

Keywords

spinal muscular atrophy; motor development; orthoses

Outcome Measures

Primary Outcomes (1)

• time and percentage of sitting, standing, walking achievement in SMA II and SMA III

  aug.2009- nov.2009

Secondary Outcomes (1)

• characteristics and percentage of orthoses for postural sitting control , standing and walking in SMA II and SMA III

  aug. 2009 - dec.2009

Study Arms (1)

SMA II and SMA III

patients with SMA II and SMA III

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients with SMA II and SMA III referred to UDGEE for rehabilitation consultation

You may qualify if:

• Clinical and genetics diagnosis of SMA II and SMA III

You may not qualify if:

• N/A

Sponsors & Collaborators

• Azienda USL Reggio Emilia - IRCCS: lead

Study Sites (1)

UDGEE Hospital S.Maria Nuova

Reggio Emilia, RE, 42100, Italy

Location

Related Publications (1)

• Wang CH, Finkel RS, Bertini ES, Schroth M, Simonds A, Wong B, Aloysius A, Morrison L, Main M, Crawford TO, Trela A; Participants of the International Conference on SMA Standard of Care. Consensus statement for standard of care in spinal muscular atrophy. J Child Neurol. 2007 Aug;22(8):1027-49. doi: 10.1177/0883073807305788.

  PMID: 17761659 BACKGROUND

MeSH Terms

Conditions

Muscular Atrophy, Spinal

Condition Hierarchy (Ancestors)

Spinal Cord Diseases; Central Nervous System Diseases; Nervous System Diseases; Motor Neuron Disease; Neurodegenerative Diseases; Neuromuscular Diseases

Study Officials

• Adriano Ferrari, MD

  Hospital S.Maria Nuova Reggio Emilia Italy

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 17, 2009
• First Posted: August 18, 2009
• Study Start: October 12, 2009
• Primary Completion: November 1, 2009
• Study Completion: April 4, 2011
• Last Updated: December 23, 2025

Record last verified: 2025-09

Locations

IT (1)