NCT00960908

Brief Summary

The objective of this study is to evaluate the safety and long-term effectiveness of coronary stenting with the zotarolimus eluting stent (ZES) and to determine clinical device and procedural success during commercial use of ZES. The investigators will compare 2nd generation ZE (Endeavor resolute, active prospective arm) with 1st generation ZES (Endeavor Sprint, retrospective arm).

Trial Health

55
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
4,000

participants targeted

Target at P75+ for all trials

Geographic Reach
1 country

19 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2009

Completed
8 months until next milestone

First Submitted

Initial submission to the registry

August 14, 2009

Completed
4 days until next milestone

First Posted

Study publicly available on registry

August 18, 2009

Completed
2.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2012

Completed
Last Updated

August 18, 2009

Status Verified

August 1, 2009

Enrollment Period

3 years

First QC Date

August 14, 2009

Last Update Submit

August 17, 2009

Conditions

Keywords

ZotarolimusDrug eluting stentEndeavor Resolute

Outcome Measures

Primary Outcomes (1)

  • Major Adverse Cardiac Events (composite of cardiac death, non-fatal MI, target lesion revascularization)

    12 months

Secondary Outcomes (9)

  • In-stent & In-segment Late Loss

    9 months

  • Stent Thrombosis

    1 year

  • Target Vessel Failure (composite of cardiac death, MI, and TVR)

    12 months

  • Any death, cardiac death, MI, TLR, TVR

    1 year

  • Composite rate of cardiac death and any MI

    1 year

  • +4 more secondary outcomes

Study Arms (2)

Resolute

Prospective recruitment of Resolute arm will start in March 2009

Device: Endeavor Resolute stents

Endeavor

The retrospective recruiting period of Endeavor arm comprises a fixed 2-year time between January 2006 and December 2008. The patients, who were treated with Endeavor in that period, will be enrolled if they agree to participate in this study.

Device: Endeavor Sprint stent

Interventions

2nd generation ZES

Also known as: Endeavor Resolute
Resolute

1st generation ZES

Also known as: Endeavor Sprint
Endeavor

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Approximately 4000 patients derived from a population of patients receiving percutaneous coronary intervention for ischemic heart disease will be enrolled in the present registry.

You may qualify if:

  • The patient agrees to participate in this study by signing the informed consent form.
  • Alternatively, a legally authorized patient representative may agree to the patient's participation in this study and sign the informed consent form.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (19)

Hallym University Sacred Heart Hospital

Anyang, South Korea

NOT YET RECRUITING

Yongnam University Medical Center

Daegu, South Korea

NOT YET RECRUITING

Chungnam National University Hospital

Daejeon, South Korea

NOT YET RECRUITING

Chonbuk National Univesity Hospital

Iksan, South Korea

NOT YET RECRUITING

Inje University Ilsan Paik Hospital

Ilsan, South Korea

NOT YET RECRUITING

National Health Insurance Corporation Ilsan Hospital

Ilsan, South Korea

RECRUITING

Gachon Kil Medical Center

Inchon, South Korea

NOT YET RECRUITING

Inha University Hospital

Inchon, South Korea

RECRUITING

Gyeongsang National University Hospital

Jinju, South Korea

NOT YET RECRUITING

Pusan National University Hospital

Pusan, South Korea

NOT YET RECRUITING

Bundang CHA Medical Center

Seongnam, South Korea

NOT YET RECRUITING

Seoul National University Bundang Hospital

Seongnam, South Korea

NOT YET RECRUITING

Gangbuk Samsung Hospital

Seoul, South Korea

NOT YET RECRUITING

Kangdong Sacred Heart Hospital

Seoul, South Korea

NOT YET RECRUITING

Seoul Boramae Hospital

Seoul, South Korea

RECRUITING

Seoul National University Hospital

Seoul, South Korea

RECRUITING

Soonchunhyang University Hospital

Seoul, South Korea

NOT YET RECRUITING

St. Vincent's Hospital

Suwon, South Korea

NOT YET RECRUITING

Uijeongbu St. Mary's Hospital

Uijeongbu-si, South Korea

NOT YET RECRUITING

MeSH Terms

Conditions

Coronary Artery Disease

Condition Hierarchy (Ancestors)

Coronary DiseaseMyocardial IschemiaHeart DiseasesCardiovascular DiseasesArteriosclerosisArterial Occlusive DiseasesVascular Diseases

Study Officials

  • Hyo-Soo Kim, MD, PhD

    Seoul National University Hospital

    STUDY CHAIR

Central Study Contacts

Kyung-Woo Park, MD, PhD

CONTACT

Il-Young Oh, MD

CONTACT

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

August 14, 2009

First Posted

August 18, 2009

Study Start

January 1, 2009

Primary Completion

January 1, 2012

Last Updated

August 18, 2009

Record last verified: 2009-08

Locations