Communicating Veins Between Adjacent Hepatic Veins: an Intra-operative Ultrasound Study

NCT00960609 | Completed

• 1 other identifier: CV-HV
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

The search for communicating veins (CVs) between adjacent hepatic veins (HVs) has drawn its rationale from living donor liver transplantation (LDLT). Parenchymal sparing procedures although HVs are resected suggest that probably their presence is underestimated. Taking profit from new improvements in ultrasound technology the investigators aim to better estimate the rate of CVs in a consecutive series of patients in whom resection of one HV at caval confluence is needed.

Conditions

Liver Tumors

Keywords

Communicating veins; hepatic venous anastomosis; intra-operative ultrasonography; hepatic resection; hepatic neoplasm; Primary and metastatic liver tumors

Outcome Measures

Primary Outcomes (1)

• First outcome was the rate of CVs detectable with e-flow IOUS along clamping of the HV for which resection could be needed.

Secondary Outcomes (1)

• Secondary outcome was safety (morbidity, mortality, blood loss, blood transfusions) of the procedure.

Study Arms (1)

caval confluence HV involvement

Patients carriers of primary or metastatic tumour with direct contact or invasion of one HV at the caval confluence.

Procedure: Ultrasound guided liver resection

Interventions

Ultrasound guided liver resection PROCEDURE

caval confluence HV involvement

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with primary and metastatic liver tumors addressed to surgical treatment

You may qualify if:

• Patients suitable for being enrolled in the present study were those carriers of primary or metastatic tumour with direct contact or invasion of one HV at the caval confluence.

You may not qualify if:

• N/A

Sponsors & Collaborators

• University of Milan: lead

Study Sites (1)

Istituto Clinico Humanitas, IRCCS

Rozzano, Milano, 20089, Italy

Location

Related Publications (6)

• Torzilli G, Procopio F, Botea F, Marconi M, Del Fabbro D, Donadon M, Palmisano A, Spinelli A, Montorsi M. One-stage ultrasonographically guided hepatectomy for multiple bilobar colorectal metastases: a feasible and effective alternative to the 2-stage approach. Surgery. 2009 Jul;146(1):60-71. doi: 10.1016/j.surg.2009.02.017.

  PMID: 19541011 BACKGROUND

• Torzilli G, Donadon M, Marconi M, Palmisano A, Del Fabbro D, Spinelli A, Botea F, Montorsi M. Hepatectomy for stage B and stage C hepatocellular carcinoma in the Barcelona Clinic Liver Cancer classification: results of a prospective analysis. Arch Surg. 2008 Nov;143(11):1082-90. doi: 10.1001/archsurg.143.11.1082.

  PMID: 19015467 BACKGROUND

• Torzilli G, Donadon M, Marconi M, Botea F, Palmisano A, Del Fabbro D, Procopio F, Montorsi M. Systematic extended right posterior sectionectomy: a safe and effective alternative to right hepatectomy. Ann Surg. 2008 Apr;247(4):603-11. doi: 10.1097/SLA.0b013e31816387d7.

  PMID: 18362622 BACKGROUND

• Torzilli G, Donadon M, Palmisano A, Del Fabbro D, Spinelli A, Makuuchi M, Montorsi M. Back-flow bleeding control during resection of right-sided liver tumors by means of ultrasound-guided finger compression of the right hepatic vein at its caval confluence. Hepatogastroenterology. 2007 Jul-Aug;54(77):1364-7.

  PMID: 17708255 BACKGROUND

• Torzilli G, Montorsi M, Del Fabbro D, Palmisano A, Donadon M, Makuuchi M. Ultrasonographically guided surgical approach to liver tumours involving the hepatic veins close to the caval confluence. Br J Surg. 2006 Oct;93(10):1238-46. doi: 10.1002/bjs.5321.

  PMID: 16953487 BACKGROUND

• Sano K, Makuuchi M, Miki K, Maema A, Sugawara Y, Imamura H, Matsunami H, Takayama T. Evaluation of hepatic venous congestion: proposed indication criteria for hepatic vein reconstruction. Ann Surg. 2002 Aug;236(2):241-7. doi: 10.1097/00000658-200208000-00013.

  PMID: 12170030 BACKGROUND

MeSH Terms

Conditions

Carcinoma, Hepatocellular; Liver Neoplasms

Condition Hierarchy (Ancestors)

Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Digestive System Diseases; Liver Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: August 17, 2009
• First Posted: August 18, 2009
• Study Start: January 1, 2008
• Last Updated: August 18, 2009

Record last verified: 2009-08

Locations

IT (1)