NCT00953693

Brief Summary

Induced pluripotent stem cells (iPSCs) are adult cells that have been genetically reprogrammed to an embryonic stem cell-like state by being forced to express genes and factors important for maintaining the defining properties of embryonic stem cells. The reprogramming of adult cells into embryonic stem (ES) cells enables the generation of patient-specific stem cells and thus has enormous potential for the treatment and analysis of degenerative diseases. In this project the investigators are going to induce pluripotent stem cells from cell cultures from skin biopsies of patients. The iPS cells will be developed for modeling diseases and drug discovery as well as basic research.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
15

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Apr 2009

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2009

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

August 3, 2009

Completed
3 days until next milestone

First Posted

Study publicly available on registry

August 6, 2009

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2010

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2010

Completed
Last Updated

December 27, 2012

Status Verified

April 1, 2010

Enrollment Period

9 months

First QC Date

August 3, 2009

Last Update Submit

December 25, 2012

Conditions

Hepatic DisordersEye Disorders

Keywords

Induced pluripotent stem cellsHepatic disordersEye disordersBlood groups

Interventions

BiopsyPROCEDURE

Skin biopsy

Eligibility Criteria

Age12 Years - 80 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

The patient who suffering from metabolic disorders

You may qualify if:

  • Donors suffering from different (specified) metabolic disorders
  • Donors suffering from different (specified) eye disorders which resulted to blindness
  • Special blood group: O Bombay

You may not qualify if:

  • None

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Royan Institute

Tehran, Tehran Province, Iran

Location

Related Publications (1)

  • Seifinejad A, Taei A, Totonchi M, Vazirinasab H, Hassani SN, Aghdami N, Shahbazi E, Yazdi RS, Salekdeh GH, Baharvand H. Generation of human induced pluripotent stem cells from a Bombay individual: moving towards "universal-donor" red blood cells. Biochem Biophys Res Commun. 2010 Jan 1;391(1):329-34. doi: 10.1016/j.bbrc.2009.11.058. Epub 2009 Nov 11.

    PMID: 19912985RESULT

Related Links

MeSH Terms

Conditions

Digestive System DiseasesEye Diseases

Interventions

Biopsy

Intervention Hierarchy (Ancestors)

CytodiagnosisCytological TechniquesClinical Laboratory TechniquesDiagnostic Techniques and ProceduresDiagnosisSpecimen HandlingDiagnostic Techniques, SurgicalSurgical Procedures, OperativeInvestigative Techniques

Study Officials

  • Hamid Gourabi, PhD

    Royan Institute

    STUDY CHAIR

  • Hossein Baharvand, PhD

    Royan Institute

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER GOV
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 3, 2009

First Posted

August 6, 2009

Study Start

April 1, 2009

Primary Completion

January 1, 2010

Study Completion

July 1, 2010

Last Updated

December 27, 2012

Record last verified: 2010-04

Locations

IR(1)