Protocol to Obtain Bone Marrow for Research

NCT00951925 | Completed DMC

• 1 other identifier: D0529
• Study Type: observational
• Target: 28
• Locations: 1 country
• Sites: 1

Brief Summary

Potential donors who are undergoing bone marrow biopsy or bone marrow donation as part of clinical care will be asked by the principal investigator (PI) if they might be interested in donating marrow for this research project. If they are interested, the PI will meet with the prospective donor to review the information contained in the informed consent document and to answer any questions the potential subject may have. Bone marrow aspirates of approximately 5cc will be obtained from the posterior iliac crest of subjects using standard techniques.

Conditions

Bone Marrow Biopsy

Keywords

diagnostic bone marrow biopsies; bone marrow harvesting for autologous BMT

Outcome Measures

Primary Outcomes (1)

• Regulation of human globin gene expression

  The purpose of this study is to determine the mechanisms that regulate human globin gene expression by analyzing the function of cell signaling pathways and the expression of other related genes and their protein products in the bone marrow cells of people without blood diseases.

  Ongoing

Study Arms (1)

No Treatment

Other: Bone Marrow Aspirate Draw

Interventions

Bone Marrow Aspirate Draw OTHER

5cc of Bone Marrow Aspirate will be drawn

No Treatment

Eligibility Criteria

• Age: 17 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

* Patients undergoing diagnostic bone marrow biopsies at the Norris Cotton Cancer Center of Dartmouth Hitchcock Medical Center (DHMC). * Patients undergoing bone marrow harvesting for autologous bone marrow transplantation.

You may qualify if:

• Patients undergoing diagnostic bone marrow biopsies at the Norris Cotton Cancer Center of DHMC.
• Patients undergoing bone marrow harvesting for autologous bone marrow transplantation.
• Normal donors undergoing bone marrow harvesting for autologous bone marrow transplantation.
• Normal persons over the age of 17 who volunteer to undergo bone marrow aspiration.

You may not qualify if:

• Normal volunteers with known allergies to lidocaine (or similar analgesics)or betadine.

Sponsors & Collaborators

• Dartmouth-Hitchcock Medical Center: lead

Study Sites (1)

Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

5cc of bone marrow aspirate

Study Officials

• Christopher H Lowrey, MD

  Dartmouth-Hitchcock Medical Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Medicine and of Pharmacology and Toxicology

Study Record Dates

• First Submitted: August 3, 2009
• First Posted: August 4, 2009
• Study Start: June 1, 2005
• Primary Completion: December 1, 2016
• Study Completion: December 1, 2018
• Last Updated: March 6, 2019

Record last verified: 2019-03

Locations

US (1)