NCT00950937

Brief Summary

The purpose of this study is to compare oxidative stress markers and the immunologic characteristics of HIV-infected and non-HIV subjects during a bout of moderate aerobic exercise followed by resistance exercises

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
28

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Jun 2006

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2006

Completed
7 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2007

Completed
1.5 years until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2008

Completed
8 months until next milestone

First Submitted

Initial submission to the registry

February 16, 2009

Completed
6 months until next milestone

First Posted

Study publicly available on registry

August 3, 2009

Completed
Same day until next milestone

Results Posted

Study results publicly available

August 3, 2009

Completed
Last Updated

August 11, 2009

Status Verified

August 1, 2009

Enrollment Period

7 months

First QC Date

February 16, 2009

Results QC Date

February 16, 2009

Last Update Submit

August 4, 2009

Conditions

HIV Infections

Outcome Measures

Primary Outcomes (1)

  • Total Glutathione

    The total glutathione content in erythrocyte concentrate at three moments: baseline, aerobic and resistance exercise.

    3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise).

Secondary Outcomes (6)

  • Catalase Activity

    3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise).

  • Glutathione S-transferase (GST)

    3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise).

  • Lipid Peroxidation

    3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise).

  • T CD4

    3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise).

  • Neutrophil Count

    3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise).

  • +1 more secondary outcomes

Study Arms (2)

HIV Group

HIV infected persons

Control Group

Non HIV-infected persons

Eligibility Criteria

Age20 Years - 55 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)
Sampling MethodNon-Probability Sample
Study Population

The participants of the HIV group were recruited at the outpatient HIV/AIDS care unit of the Hospital de Clínicas de Porto Alegre (HCPA), whereas the control group (non-HIV) was formed by volunteers of the city of Porto Alegre, Rio Grande do Sul, Brazil

You may qualify if:

  • HIV Group:without contraindications for exercise training; to highly active antiretroviral therapy (HAART) for at least 6 months before enrollment; be classified as low level of physical activity by international physical activity questionnaire (IPAQ) and did not use antioxidant supplements.
  • Control Group:negative result for HIV-1 test and the other criteria described above

You may not qualify if:

  • Subjects with previous history of cardiovascular and neurological disease, diabetes, dyslipidemia, tobacco using, physical disability and pregnant women were excluded from the study.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Outpatient HIV/AIDS care unit of the Hospital de Clínicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil

Location

MeSH Terms

Conditions

HIV Infections

Condition Hierarchy (Ancestors)

Blood-Borne InfectionsCommunicable DiseasesInfectionsSexually Transmitted Diseases, ViralSexually Transmitted DiseasesLentivirus InfectionsRetroviridae InfectionsRNA Virus InfectionsVirus DiseasesGenital DiseasesUrogenital DiseasesImmunologic Deficiency SyndromesImmune System Diseases

Results Point of Contact

Title
Pedro Dall'Ago
Organization
Hospital de Clínicas de Porto Alegre
pdallago@pq.cnpq.br
555133038751

Study Officials

  • Pedro Dall'Ago, Professor

    Hospital de Clinicas de Porto Alegre

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

February 16, 2009

First Posted

August 3, 2009

Study Start

June 1, 2006

Primary Completion

January 1, 2007

Study Completion

July 1, 2008

Last Updated

August 11, 2009

Results First Posted

August 3, 2009

Record last verified: 2009-08

Locations

BR(1)