Carotid Intima-media Thickness (IMT) and Large-vessel Atherosclerosis by Multidetector Computed Tomography (MDCT)

NCT00949169 | Completed DMC

• 1 other identifier: Eulji07-34
• Study Type: observational
• Target: 71
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study was to investigate whether carotid IMT can predict the presence of more advanced atherosclerosis such as carotid stenosis, coronary or intracranial artery disease by MDCT and whether MDCT could be useful next step for more aggressive treatment modality in Korean type 2 diabetic patients.

Conditions

Type 2 Diabetes

Keywords

Atherosclerosis; Carotid IMT; Multidetector CT; Type 2 diabetes

Outcome Measures

Primary Outcomes (1)

• We compared prevalence of large artery stenosis according to carotid IMT group and evaluated whether maximal IMT ≥ 1.0 mm could predict for significant CAD by MDCT.

  17 months

Secondary Outcomes (1)

• We performed invasive coronary angiography in some patients (N=14) and analyzed association for degrees of CAD between two angiographic methods.

  17 months

Study Arms (1)

Carrotid IMT group according to maximal IMT

We defined increased IMT group as whom had maximal IMT ≥ 1.0 mm.

Eligibility Criteria

• Age: 40 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

type 2 diabetic patients who had multiple cardiovascular risk factors

You may qualify if:

• Type 2 diabetic patients who had multiple cardiovascular risk factors were recruited.
• Patients who had atypical chest pain, EKG abnormality (ischemic ST-T changes or abnormal Q-wave), or history of previous cardiovascular disease were also included.

You may not qualify if:

• Acute coronary SD, serum Cr\>1.4 mg/dL, history of allergy to iodinated contrast dye were excluded.

Sponsors & Collaborators

• Eulji University Hospital: lead

Study Sites (1)

Eulji University Hospital

Seoul, 139-711, South Korea

Location

MeSH Terms

Conditions

Diabetes Mellitus, Type 2; Atherosclerosis

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Kyung Wan Min, MD., PhD.

  Department of Internal Medicine, Eulji University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: July 29, 2009
• First Posted: July 30, 2009
• Study Start: April 1, 2006
• Study Completion: July 1, 2007
• Last Updated: July 30, 2009

Record last verified: 2009-07

Locations

KR (1)