Pharmacogenetics of Antifolate Drugs in Autoimmune Diseases in Taiwan
1 other identifier
observational
N/A
0 countries
N/A
Brief Summary
BACKGROUND. Polymorphisms occur in several genes encoding key enzymes in the folate pathway may affect drug metabolism in patients with rheumatoid arthritis. Whether these genetic variations contribute to differential responses to antifolate drug in patients with rheumatoid arthritis (RA) remains to be investigated in the Taiwanese population. OBJECTIVE. The goal of the present study is to investigate the interactions between genetic variations in folate genes and the efficacy/side effects of anti-folate disease-modifying anti-rheumatic drug in Taiwan. DESIGN. A cross-sectional study involving patients with RA were enrolled from TCVGH. Disease activity, drug efficacy and associated side-effects were assessed. Genotypes in folylpoly-gamma-glutamate synthetase and reduced folate carrier were determined by RFLP or pyrosequencing.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
Started Feb 2007
Shorter than P25 for all trials
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Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2008
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2008
CompletedFirst Submitted
Initial submission to the registry
July 22, 2009
CompletedFirst Posted
Study publicly available on registry
July 23, 2009
CompletedJuly 23, 2009
July 1, 2009
1 year
July 22, 2009
July 22, 2009
Conditions
Study Arms (2)
RA with drug
RA without drug
Eligibility Criteria
A cross-sectional study involving 150 patients with RA were enrolled from TCVGH.
You may qualify if:
- Male/female age \>18
- RA diagnosed
You may not qualify if:
- Must not be pregnant/breastfeeding
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
July 22, 2009
First Posted
July 23, 2009
Study Start
February 1, 2007
Primary Completion
February 1, 2008
Study Completion
February 1, 2008
Last Updated
July 23, 2009
Record last verified: 2009-07