NCT00930657|Terminated
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Sponsor study identifier
Secondary identifiers
observational
13
1 country
1
Study Start
June 26, 2009
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
August 12, 2019
Date type not reportedThis date has not been verified as actual or estimated.
Objective: To examine respiratory/physiological and subjective responding as well as genetic transmission among offspring of parents with a history of or current panic disorder (PD) diagnosis to determine whether diagnoses/symptoms, endophenotypes, or genetic profiles in offspring is differentially related to parent PD subtypes (i.e., respiratory and non-respiratory panic). Study population: Approximately 400 offspring of about 200 parents with current or past PD. Approximately 200 offsping/100 parents with PD will be enrolled at NIH/NIMH and the remainder at Virginia Commonwealth University in Richmond, VA. Design: A high-risk family design will be used wherein parents with either a current or past diagnosis of PD who have an offspring(s) (ages 9 to 20) will be recruited. \<TAB\> Outcome measures: Outcome measures will include physiological recordings of respiratory, cardiac, and electrodermal responding during a 10 minute baseline followed by 15 minutes of 5% carbon dioxide enriched air (CO2). Research participants also will complete parent and child self-report measures and provide a DNA sample using a saliva protocol. A full listing of self-reports is provided in the Outcome Measures Section.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 12, 2019
Date type not reportedThis date has not been verified as actual or estimated.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
June 26, 2009
Date type not reportedThis date has not been verified as actual or estimated.
June 27, 2009
Actual (reported)June 30, 2009
Actual (reported)August 12, 2019
Date type not reportedThis date has not been verified as actual or estimated.
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, 20892, United States
Abrams K, Rassovsky Y, Kushner MG. Evidence for respiratory and nonrespiratory subtypes in panic disorder. Depress Anxiety. 2006;23(8):474-81. doi: 10.1002/da.20179.
Battaglia M, Ogliari A, Harris J, Spatola CA, Pesenti-Gritti P, Reichborn-Kjennerud T, Torgersen S, Kringlen E, Tambs K. A genetic study of the acute anxious response to carbon dioxide stimulation in man. J Psychiatr Res. 2007 Dec;41(11):906-17. doi: 10.1016/j.jpsychires.2006.12.002. Epub 2007 Jan 24.
Daniel S Pine, M.D.
National Institute of Mental Health (NIMH)
13 participants (actual enrollment reported by the registry).
First Submitted
June 27, 2009
First Posted
June 30, 2009
Study Start
June 26, 2009
Date type not reportedThis date has not been verified as actual or estimated.
Evaluation of Clonazepam and Paroxetine for Panic Disorder With Depression
Contact the study team to confirm eligibility.
Biber B, Alkin T. Panic disorder subtypes: differential responses to CO2 challenge. Am J Psychiatry. 1999 May;156(5):739-44. doi: 10.1176/ajp.156.5.739.
Study Completion
August 12, 2019
Date type not reportedThis date has not been verified as actual or estimated.
Last Updated
August 14, 2019
Record last verified: 2019-08-12
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