NCT00930423|Completed
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Sponsor study identifier
observational
25
1 country
1
Study Start
August 2009
Actual (reported)Primary Completion
July 2015
Actual (reported)Study Completion
July 2015
Actual (reported)Atypical hemolytic uraemic syndrome is caused by defects in the regulating factors in the alternative pathway of the complement system. Triggering can cause an uncontrolled complement activation with endothelial damage and thrombotic micro-angiopathy, especially in the kidneys. This can result in endstage renal failure. Complement activation during hemodialysis has been described as a result of contact between blood and the dialysis membrane. Our hypothesis is that patients with atypical hemolytic uraemic syndrome have a stronger complement activation during hemodialysis than patients with another underlying kidney disease. This could be a reason to treat patients with endstage renal failure due to atypical hemolytic uraemic syndrome preferentially with peritoneal dialysis instead of hemodialysis.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 2015
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
June 29, 2009
Actual (reported)June 30, 2009
Actual (reported)August 2009
Actual (reported)July 2015
Actual (reported)July 2015
Actual (reported)C3a-des-Arg measuring (as a marker of activation).
at time 0, at 15 minutes, at 60 minutes and at 180 minutes
white blood cell count
before and after 15 minutes of hemodialysis
patients with endstage renal failure due to atypical uraemic syndrome treated with hemodialysis.
patiënts with endstage renal failure due to a non complement consuming nephropathy treated with hemodialysis.
patients with endstage renal failure treated in het University Hospital of Ghent
University Hospital Ghent
Ghent, 9000, Belgium
blood samples
Raymond Vanholder, MD, PhD
University Hospital, Ghent
25 participants (actual enrollment reported by the registry).
First Submitted
June 29, 2009
First Posted
June 30, 2009
Study Start
August 2009
Actual (reported)Contact the study team to confirm eligibility.
Primary Completion
July 2015
Actual (reported)Study Completion
July 2015
Actual (reported)Last Updated
December 15, 2022
Record last verified: 2014-12
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Source: ClinicalTrials.gov.
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