Effects of Cardiac Rehabilitation for Individuals With Transient Ischemic Attack

NCT00929994 | Completed Results

• 1 other identifier: Brooks - 001
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

It is hypothesized that the addition of formal cardiac rehabilitation to standard care will result in long-term improvements in cardiovascular fitness and functional capacity in individuals who have suffered a transient ischemic attack (TIA) or minor stroke. Furthermore, it is proposed that the addition of cardiac rehabilitation will influence depressive symptoms and cognition.

Conditions

Transient Ischemic Attack

Keywords

cardiac rehab

Outcome Measures

Primary Outcomes (2)

• Functional Walk Test

  6 minute walk test: the longest distance a person can walk for a duration of 6 minutes

  Baseline, 3 months, 6 months (Six Minute Walk Distance)

• Cardiovascular Fitness (VO2peak)

  To measure cardiovascular fitness, a stress test on either an upright cycle ergometer (Ergoselect 200P, Germany), or a treadmill (same modality pre- and post-training) was performed depending on patient balance and comfort.

  Baseline (after the 3 month non-intervention period) and after 6 months of participation.

Secondary Outcomes (2)

• Center for Epidemiologic Studies Depression Scale (CES-D).

  Baseline and 3 months (non-intervention period), after 6 months of cardiac rehabilitation participation

• Cognition

  Baseline and 3 months (non-intervention period), after 6 months of cardiac rehabilitation participation

Study Arms (1)

Exercise

Following a 3 month non intervention period, participants will participate in Cardiac Rehabilitation, carrying out an exercise program which will last 6 months and combine both resistance and aerobic training.

Behavioral: Cardiac Rehabilitation

Interventions

Cardiac Rehabilitation BEHAVIORAL

Individualized cardiac rehabilitation for 6 months, including health education sessions, as well as supervised exercise classes which include aerobic and resistance training.

Exercise

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

TIA

You may qualify if:

• Diagnosed with TIA
• Three months post-TIA
• Ability to understand the process and instructions for exercise training and provide informed consent

You may not qualify if:

• Resting Blood Pressure greater than 160/100 despite medication
• Other cardiovascular morbidity which would limit exercise tolerance (heart failure, abnormal BP responses or STsegment depression \> 2 mm, symptomatic aortic stenosis, complex arrhythmias)
• Current and extensive exercise participation
• Hypertrophic Cardiomyopathy
• Unstable Angina
• Orthostatic BP decrease of \> 20 mm Hg with symptoms
• Other musculoskeletal impairments which would limit the participants ability to walk sufficient durations
• Pain or other co-morbidities (e.g., unclipped aneurysms, uncontrolled seizures etc.) which would preclude participation
• Cognitive or behavioural issues that would limit participation in exercise testing and training

Sponsors & Collaborators

• Toronto Rehabilitation Institute: lead
• Heart and Stroke Foundation of Canada: collaborator

Study Sites (1)

Toronto Rehabilitation Institute - Rumsey Center

Toronto, Ontario, M4G 1R7, Canada

Location

MeSH Terms

Conditions

Ischemic Attack, Transient

Interventions

Cardiac Rehabilitation

Condition Hierarchy (Ancestors)

Brain Ischemia; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Health Services; Health Care Facilities Workforce and Services

Limitations and Caveats

This study was conducted in a single centre located in a large city centre and may lack generalizability to other programs, including those where CR services are not publicly funded.

Results Point of Contact

• Title: Dr.
• Organization: Toronto Rehab

dina.brooks@utoronto.ca

4169781739

Study Officials

• Dina Brooks, PhD

  Toronto Rehabilitation Institute

  PRINCIPAL INVESTIGATOR

• William E McIllroy, PhD

  University of Waterloo

  PRINCIPAL INVESTIGATOR

• Paul Oh, MD

  Toronto Rehabilitation Institute

  PRINCIPAL INVESTIGATOR

• Sandra Black, MD

  Sunnybrook and Women's College Health Centre

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: June 29, 2009
• First Posted: June 30, 2009
• Study Start: March 1, 2010
• Primary Completion: November 1, 2014
• Study Completion: November 1, 2014
• Last Updated: April 23, 2019
• Results First Posted: April 23, 2019

Record last verified: 2019-04

Locations

CA (1)