NCT00925561

Brief Summary

Coronary artery disease (CAD) is an important health concern for African Americans, who are diagnosed with CAD at high rates. Coronary artery calcification, which is characterized by calcium deposits in the coronary arteries, is a contributing factor to CAD. This study will examine the possible genetic causes of coronary artery calcification in African Americans.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
752

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2009

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2009

Completed
6 months until next milestone

First Submitted

Initial submission to the registry

June 19, 2009

Completed
3 days until next milestone

First Posted

Study publicly available on registry

June 22, 2009

Completed
3.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2013

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2013

Completed
Last Updated

June 19, 2013

Status Verified

June 1, 2013

Enrollment Period

4.2 years

First QC Date

June 19, 2009

Last Update Submit

June 18, 2013

Conditions

Atherosclerosis

Keywords

Coronary Artery Calcification

Outcome Measures

Primary Outcomes (1)

  • Coronary Artery Calcification

    Measured during participants' single study visit

Study Arms (1)

No treatment

Eligibility Criteria

Age20 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

The study population will come from Jackson, MS and will include all men and women belonging to sibships that previously participated in the second GENOA exam. The sampling frame includes 1482 African Americans in 627 sibships providing 1552 sibling pairs from Jackson, Mississippi.

You may qualify if:

  • Participated in the second GENOA exam in Jackson, Mississippi and is alive and willing to participate

You may not qualify if:

  • Reported a history of heart attack, stroke, or coronary or non-coronary heart surgery

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

Blood to measure risk factors and stored DNA for genetic studies

MeSH Terms

Conditions

Atherosclerosis

Condition Hierarchy (Ancestors)

ArteriosclerosisArterial Occlusive DiseasesVascular DiseasesCardiovascular Diseases

Study Officials

  • Patricia Peyser, Ph.D.

    University of Michigan

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor of Epidemiology

Study Record Dates

First Submitted

June 19, 2009

First Posted

June 22, 2009

Study Start

January 1, 2009

Primary Completion

April 1, 2013

Study Completion

April 1, 2013

Last Updated

June 19, 2013

Record last verified: 2013-06

Locations

US(1)