Effect of Passive Smoking on Platelet Function and Endothelial Function

NCT00923988 | Completed

• 1 other identifier: SHS-EF
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Passive smoking is associated with an increased risk for cardiovascular events. However, the exact mechanisms by which passive smoking affects cardiovascular health are not entirely understood. In the present study, the researchers investigate the effects of short-term exposure to secondhand smoke on platelet function and peripheral microvascular endothelial function in healthy individuals. For this purpose, platelet function and endothelial function are measured before and after a 1-hour exposure to secondhand smoke in a concentration that is encountered in bars and restaurants without smoke-free policies. The researchers' hypothesis is that short-term exposure leads to platelet activation and impairment of endothelial function.

Conditions

Endothelial Function; Platelet Aggregation

Keywords

Secondhand smoke; passive smoking; platelet function; endothelial function

Outcome Measures

Primary Outcomes (1)

• Change in platelet aggregation and/or endothelial function

  12-24 hours

Interventions

secondhand smoke exposure OTHER

Participants will be exposed to secondhand smoke for one hour. As a measure of secondhand smoke exposition, room carbon monoxide concentration will be continuously measured using an Ambient Carbon Monoxide Monitor APMA-360 and kept constant between 4.5-6.0 ppm. Levels in this magnitude are typically seen in smoking areas of restaurants and bars.

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• healthy individuals
• nonsmokers
• no regular medication (in particular no drugs affecting platelet function or vascular function)

Sponsors & Collaborators

• Kantonsspital Graubünden: lead

Study Sites (1)

Kantonsspital Graubuenden

Chur, 7000, Switzerland

Location

Study Officials

• Piero O. Bonetti, MD

  Division of Cardiology, Department of Internal Medicine, Kantonsspital Graubuenden, Loestrasse 170, CH-7000 Chur, Switzerland

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: June 17, 2009
• First Posted: June 18, 2009
• Study Start: June 1, 2009
• Primary Completion: August 1, 2009
• Study Completion: August 1, 2009
• Last Updated: August 11, 2009

Record last verified: 2009-08

Locations

CH (1)