Biospecimen Repository for Cardiac Arrhythmias at the Cleveland Clinic

NCT00921986 | Recruiting DMC

• 1 other identifier: 09-176
• Study Type: observational
• Target: 2,000
• Locations: 1 country
• Sites: 1

Brief Summary

Biorepository of blood and or tissue samples from patients presenting with cardiac arrhythmia syndromes.

Conditions

Arrhythmias, Cardiac

Keywords

genetics; biorepository; cardiac death; atrial fibrillation; ventricular fibrillation; ventricular tachycardia; supraventricular tachycardias; premature ventricular complexes; premature atrial complexes; atrioventricular and intraventricular blocks; sinus node dysfunction; syncope; vasovagal reactivity; postural orthostatic tachycardia syndrome

Outcome Measures

Primary Outcomes (1)

• Genetic variants associated with arrhythmias

  Genome-wide association study of arrhythmias

  Baseline

Study Arms (2)

Arrhythmias

Patients with arrhythmias

Control Subjects

Subjects that do not have a history of cardiac arrhythmias.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients undergoing arrhythmia procedures, cardiac surgery or inpatient or outpatient evaluations for arrhythmias at the Cleveland Clinic or from outside collaborative institutions or from other clinical trials.

You may qualify if:

• Male or female at least 18 years old
• Subjects with a history of or current cardiac arrhythmia, family members of subjects with cardiac arrhythmias, or no cardiac arrhythmia if a Control Subject.

You may not qualify if:

• Subjects previously enrolled in the Arrhythmia BioBank

Sponsors & Collaborators

• The Cleveland Clinic: lead

Study Sites (1)

Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Biospecimens to be collected: DNA, RNA, plasma, \& serum. Also tissue may be collected.

MeSH Terms

Conditions

Arrhythmias, Cardiac; Death; Atrial Fibrillation; Ventricular Fibrillation; Tachycardia, Ventricular; Tachycardia, Supraventricular; Ventricular Premature Complexes; Atrial Premature Complexes; Sick Sinus Syndrome; Syncope; Postural Orthostatic Tachycardia Syndrome

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Tachycardia; Cardiac Conduction System Disease; Cardiac Complexes, Premature; Arrhythmia, Sinus; Heart Block; Unconsciousness; Consciousness Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Orthostatic Intolerance; Primary Dysautonomias; Autonomic Nervous System Diseases

Study Officials

• Mina K. Chung, MD

  The Cleveland Clinic

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Mina K. Chung, MD

CONTACT

216.444.2290; chungm@ccf.org

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: June 15, 2009
• First Posted: June 17, 2009
• Study Start: March 1, 2009
• Primary Completion (Estimated): December 1, 2035
• Study Completion (Estimated): December 1, 2035
• Last Updated: September 10, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)