Hemangioma Growth During the First 6 Months of Life

NCT00911781 | Completed

• 1 other identifier: hemangioma photo study
• Study Type: observational
• Target: 36
• Locations: 1 country
• Sites: 2

Brief Summary

One of the most important and unique characteristics of infantile hemangiomas is their dramatic growth during early infancy. Most hemangiomas are either absent at birth or barely evident as a small scratch or bruise-like area. A recent study emphasized how early hemangioma growth occurs. In this study by 3 months of age, hemangiomas had reached 80% of their final size, and by 5 months of age, 80% had already stopped growing. Unfortunately the average age when most infants are seen by specialists is often at 5 months of age or later, a time when most growth is already completed. Researchers at the University of California, San Francisco, the Medical College of Wisconsin, and at the Mayo Clinic are interested in studying hemangioma growth at even earlier ages, before 3 months of age, which is before most patients are ever seen by dermatologists or other specialists. For this study are requesting that parents of children older than 3 months of age with hemangiomas send us a series of photographs of their child which demonstrates this early growth. Ideally the photographs would show your child (including the area of the hemangioma of course) at weekly or every other week intervals up until age least 3 to 6 months of age. This will probably not be difficult if the hemangioma is on the face but we would be interested in other body locations as well, if available. We are using these photographs to analyze early hemangioma growth patterns, to see if there is a period of especially rapid growth, and to help determine if there is a specific time before which specialty referral should occur. We are interested in all sizes of hemangiomas, from small to large. Of greatest importance is that the photos be at frequent intervals (every 1 to 2 weeks is ideal) and of sufficient quality to be able to evaluate the appearance of the hemangioma.

Conditions

Hemangiomas of Infancy

Keywords

Infantile hemangioma

Outcome Measures

Primary Outcomes (1)

• hemangioma growth

  up to 8 weeks

Study Arms (1)

Infants with infantile hemangiomas

Other: No intervention

Interventions

No intervention OTHER

We are only asking for photographs from parents.

Infants with infantile hemangiomas

Eligibility Criteria

• Age: 3 Months - 5 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Patients are being recruited from a national hemangioma support website (NOVA)and from community clinics atthe University of California, San Francisco. We hope to reach more interested parents through registering our protocol.

You may qualify if:

• Children older than 3 months of age who have or have had a diagnosis of an infantile hemangioma. The parents of these children will be able to provide us with frequent (weekly to biweekly) photographs of the patient's hemangioma(s) during the first 3-6 months of life.
• These hemangiomas must have a superficial component that can be seen. Parents must consent to the use of their child's photographs in this study.

You may not qualify if:

• Current age less than 3 months. Patient who do not have an infantile hemangioma (as determined by the investigators). Patients whose photographs are not of sufficient quality or frequency in order to be evaluated for this study.

Sponsors & Collaborators

• University of California, San Francisco: lead
• Mayo Clinic: collaborator
• Medical College of Wisconsin: collaborator

Study Sites (2)

University of California, San Francisco

San Francisco, California, 94115, United States

Location

Mayo Clinic

Rochester, Minnesota, 55901, United States

Location

Related Publications (1)

• Chang LC, Haggstrom AN, Drolet BA, Baselga E, Chamlin SL, Garzon MC, Horii KA, Lucky AW, Mancini AJ, Metry DW, Nopper AJ, Frieden IJ; Hemangioma Investigator Group. Growth characteristics of infantile hemangiomas: implications for management. Pediatrics. 2008 Aug;122(2):360-7. doi: 10.1542/peds.2007-2767.

  PMID: 18676554 BACKGROUND

Related Links

• Tollefson MM, Frieden IJ. Early growth of infantile hemangiomas: what parents' photographs tell us. Pediatrics. 2012 Aug;130(2):e314-20. doi: 10.1542/peds.2011-3683. Epub 2012 Jul 23. PubMed PMID: 22826568.

MeSH Terms

Conditions

Hemangioma, Capillary

Condition Hierarchy (Ancestors)

Hemangioma; Neoplasms, Vascular Tissue; Neoplasms by Histologic Type; Neoplasms

Study Officials

• Ilona J Frieden, MD

  University of California, San Francisco

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 29, 2009
• First Posted: June 2, 2009
• Study Start: February 1, 2009
• Primary Completion: May 1, 2011
• Study Completion: December 1, 2011
• Last Updated: February 5, 2013

Record last verified: 2013-02

Locations

US (2)