Insulin Resistance And End Stage Renal Disease: The Role Of Retinol Binding Protein 4

NCT00910130 | Unknown

• 1 other identifier: RBP4
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to determine whether Retinol binding protein 4 has a role in insulin resistance development in patients suffering from end stage renal disease on hemodialysis.

Conditions

Insulin Resistance; Diabetes; End Stage Renal Disease

Keywords

Retinol Binding Protein 4; Insulin Resistance; Diabetes; End Stage Renal Disease; Dialysis; Nutrition

Study Arms (2)

End Stage Renal Disease

Patients suffering from End Stage Renal Disease on Hemodialysis, without Diabetes

Control

Healthy people, with normal Renal Function and without Diabetes, matched with "ESRD group" for age, gender, BMI

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Ambulatory patients or primary care clinic for "End Stage Renal Disease group;" Blood donors or primary care clinic for "Control group"

You may qualify if:

• Hemodialysis for "End Stage Renal Disease group"
• Normal Renal Function for "Control group"

You may not qualify if:

• Diabetes
• Malnutrition
• Malignancy
• Acute Infection
• Chronic Active Infection

Sponsors & Collaborators

• Fondazione IRCCS Policlinico San Matteo di Pavia: lead

Study Sites (1)

Giovanni Piotti

Pavia, 27100, Italy

RECRUITING

Related Publications (2)

• Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L, Kahn BB. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 2005 Jul 21;436(7049):356-62. doi: 10.1038/nature03711.

  PMID: 16034410 RESULT

• Graham TE, Yang Q, Bluher M, Hammarstedt A, Ciaraldi TP, Henry RR, Wason CJ, Oberbach A, Jansson PA, Smith U, Kahn BB. Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med. 2006 Jun 15;354(24):2552-63. doi: 10.1056/NEJMoa054862.

  PMID: 16775236 RESULT

Biospecimen

Retention: SAMPLES WITH DNA

Serum Subcutaneous adipose tissue

MeSH Terms

Conditions

Insulin Resistance; Diabetes Mellitus; Kidney Failure, Chronic

Condition Hierarchy (Ancestors)

Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Renal Insufficiency, Chronic; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Giovanni Piotti, MD

  Unit Of Nephrology, Dialysis And Transpantation, IRCCS Fondazione Policlinico San Matteo, Pavia Italy

  PRINCIPAL INVESTIGATOR

• Teresa Rampino, MD

  Unit Of Nephrology, Dialysis And Transpantation, IRCCS Fondazione Policlinico San Matteo, Pavia Italy

  STUDY DIRECTOR

• Antonio Dal Canton, MD

  Unit Of Nephrology, Dialysis And Transpantation, IRCCS Fondazione Policlinico San Matteo, Pavia Italy

  STUDY CHAIR

Central Study Contacts

Giovanni Piotti, MD

CONTACT

+390382502590; gpiotti@yahoo.it

Teresa Rampino, MD

CONTACT

+390382503896; t.rampino@smatteo.pv.it

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: May 28, 2009
• First Posted: May 29, 2009
• Study Start: July 1, 2008
• Last Updated: May 29, 2009

Record last verified: 2009-05

Locations

IT (1)