Lebanese Interhospital Pneumococcal Surveillance Program

NCT00901602 | Recruiting

• 1 other identifier: PNEUMOSurv1LIPSP
• Study Type: observational
• Target: 700
• Locations: 1 country
• Sites: 1

Brief Summary

Streptococcus pneumoniae (pneumococcus) is a bacterium that causes severe infections in children and adults such as meningitis, pneumonia, and blood stream infection. There are many types of these bacteria defined by the type of sugar coat that they have. These are classified as serotypes. There are common serotypes that cause severe disease and are preventable by vaccination of children. Other less common types are more difficult to prevent. The investigators aim to determine the serotypes that cause invasive pneumococcal disease in Lebanon and to study their sensitivity to different antibiotics. The investigators will collect bacterial isolates from different hospitals in Lebanon isolated from the blood or spinal fluid of patients with invasive pneumococcal disease. This information will help the investigators determine the usefulness of available pneumococcal vaccines in preventing these infections. The data will be distributed to all primary care physicians treating children in Lebanon and will be shared with the Ministry of Health.

Conditions

Pneumonia; Meningitis; Sepsis; Bacteremia

Keywords

streptococcus pneumoniae; pneumococcus; pneumonia; meningitis; serotypes; bacteremia; sepsis

Outcome Measures

Primary Outcomes (1)

• Serotype prevalence of S. pneumoniae in invasive pneumococcal disease

  yearly

Secondary Outcomes (1)

• Determine the antibiotic sensitivity of S. pneumoniae and the association with specific serotypes

  yearly

Eligibility Criteria

• Age: 1 Day+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients with invasive pneumococcal disease with positive culture of S. pneumoniae from a normally sterile site (blood, CSF, etc.)

You may qualify if:

• Samples included in the study are those that are:
• culture proven
• invasive pneumococcal infections
• in patients of all ages admitted to different hospitals all over Lebanon
• Acceptable samples include:
• positive isolates from blood
• cerebrospinal fluid
• other normally sterile body sites such as empyema fluid, abscesses, joint fluid, middle ear fluid obtained by tympanocentesis in the operating room, and lung needle aspiration

You may not qualify if:

• non S. pneumoniae isolates

Sponsors & Collaborators

• American University of Beirut Medical Center: lead
• PneumoADIP: collaborator
• Pfizer: collaborator

Study Sites (1)

American University of Beirut

Beirut, 113-6044, Lebanon

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Bacterial isolates

MeSH Terms

Conditions

Pneumonia; Meningitis; Sepsis; Bacteremia

Condition Hierarchy (Ancestors)

Respiratory Tract Infections; Infections; Lung Diseases; Respiratory Tract Diseases; Neuroinflammatory Diseases; Nervous System Diseases; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Bacterial Infections; Bacterial Infections and Mycoses

Study Officials

• Ghassan S Dbaibo, M.D.

  American University of Beirut Medical Center

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ghassan S Dbaibo, M.D.

CONTACT

+961-1-749235; gdbaibo@aub.edu.lb

Mireille Lteif, RN

CONTACT

+961-1-350000; ml12@aub.edu.lb

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: May 8, 2009
• First Posted: May 14, 2009
• Study Start: October 1, 2005
• Primary Completion (Estimated): October 1, 2030
• Study Completion (Estimated): October 1, 2030
• Last Updated: February 3, 2023

Record last verified: 2023-02

Locations

LE (1)