NCT00900029

Brief Summary

This is a 24-week observational follow safety study for Study 802-247-09-015.

Trial Health

90
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
206

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jun 2009

Typical duration for all trials

Geographic Reach
2 countries

30 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 11, 2009

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 12, 2009

Completed
20 days until next milestone

Study Start

First participant enrolled

June 1, 2009

Completed
2.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2011

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2012

Completed
4.7 years until next milestone

Results Posted

Study results publicly available

September 29, 2016

Completed
Last Updated

August 2, 2017

Status Verified

September 1, 2016

Enrollment Period

2.3 years

First QC Date

May 11, 2009

Results QC Date

September 28, 2016

Last Update Submit

June 27, 2017

Conditions

Keywords

Venous Leg UlcerVenous Stasis UlcerVLUVSULeg UlcerLeg Wound

Outcome Measures

Primary Outcomes (2)

  • The Number of Participants With Closed Target Ulcers at Each Visit

    At each visit the status of closed target ulcers was evaluated as remained closed or re-opened.

    Over the 24-week study period, at each of the bi-monthly visits

  • Number of Subjects With Target Wound Closed for the First Time During the Study Period.

    At each visit the status of open target ulcers was evaluated as "remained open" or "closed".

    Over the 24-week study period, at each of the bi-monthly visits

Study Arms (2)

No HP802 Treatment

Treatment received in Study 802-247-09-015 was HP802

Biological: No HP802 Treatment

No HP802 Vehicle Treatment

Treatment received in Study 802-247-09-015 was HP802 Vehicle

Other: No HP802 Vehicle Treatment

Interventions

No HP802 Treatment
No HP802 Vehicle Treatment

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Subjects who participated in Study No. 802-247-09-015 - "A Phase II Randomized, Double Blind, Placebo Controlled Dose Finding Study Investigating the Efficacy of HP802-247 in Venous Leg Ulcers" and agreed to continue with the follow-up study.

You may qualify if:

  • Provide informed consent
  • Willing to comply with protocol instructions, including allowing all study assessments.
  • Subject was randomized in HP 802-247-09-015 and received at least one application of a test article, whether active or placebo.
  • Subject has ended their participation in HP 802-247-09-015 by virtue of completing the study, or by dropping out prior to completion.

You may not qualify if:

  • Subjects who refuse to provide written informed consent will be excluded from this trial.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (30)

University of AZ College of Medicine

Tucson, Arizona, 85724, United States

Location

Center for Clinical Research

Castro Valley, California, 94546, United States

Location

ILD Consulting, Inc.

Encinitas, California, 92024, United States

Location

Vascular Surgery Associates

Los Angeles, California, 90048, United States

Location

UCSD Wound Treatment and Research Center

San Diego, California, 92013, United States

Location

University of Miami

Miami, Florida, 33186, United States

Location

Doctors Research Network

South Miami, Florida, 33143, United States

Location

Robert J. Snyder

Tamarac, Florida, 33321, United States

Location

Northwestern University Feinberg School of Medicine

Chicago, Illinois, 60154, United States

Location

Passavant Area Hospital

Jacksonville, Illinois, 62650, United States

Location

Rosalind Franklin University

North Chicago, Illinois, 60064, United States

Location

Southern Illinois University

Springfield, Illinois, 62702, United States

Location

Johns Hopkins Wound Center

Baltimore, Maryland, 21231, United States

Location

Boston Medical Center

Boston, Massachusetts, 02118, United States

Location

New England Sinai Hospital

Stoughton, Massachusetts, 02972, United States

Location

Advanced Foot and Ankle Center

Las Vegas, Nevada, 89119, United States

Location

Vincent Giacalone

Emerson, New Jersey, 07630, United States

Location

St. Luke's Roosevelt Hospital Center

New York, New Jersey, 10025, United States

Location

Overglook Hospital Wound Healing Program

Summit, New Jersey, 07901, United States

Location

University of North Carolina

Chapel Hill, North Carolina, 27599, United States

Location

Harrisburg Foot and Ankle Center

Harrisburg, Pennsylvania, 17112, United States

Location

Center for Advanced Wound Care

Reading, Pennsylvania, 19601, United States

Location

Arlington Research Center

Arlington, Texas, 76011, United States

Location

Wound Care Consultants

Dallas, Texas, 75093, United States

Location

Southwest Regional Wound Care Center

Lubbock, Texas, 79410, United States

Location

Peripheral Vascular Associates

San Antonio, Texas, 78205, United States

Location

Dixie Regional Medical Center's Wound Clinic

St. George, Utah, 84770, United States

Location

Lake Washington Vascular, PLLC

Bellevue, Washington, 98004, United States

Location

Providence Sacred Heart Medical Center Wound Clinic

Spokane, Washington, 99204, United States

Location

Aging Rehabilitation & Geriatric Care Research Center

London, Ontario, N6C5J1, Canada

Location

MeSH Terms

Conditions

Varicose UlcerLeg Ulcer

Condition Hierarchy (Ancestors)

Varicose VeinsVascular DiseasesCardiovascular DiseasesSkin UlcerSkin DiseasesSkin and Connective Tissue Diseases

Results Point of Contact

Title
Jaime E Dickerson, PhD
Organization
Smith & Nephew, Inc.

Study Officials

  • Hebert B Slade, MD, FAAAAI

    Healthpoint

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
LTE60
Restrictive Agreement
Yes

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 11, 2009

First Posted

May 12, 2009

Study Start

June 1, 2009

Primary Completion

October 1, 2011

Study Completion

January 1, 2012

Last Updated

August 2, 2017

Results First Posted

September 29, 2016

Record last verified: 2016-09

Data Sharing

IPD Sharing
Will not share

Locations