NCT00899366

Brief Summary

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This laboratory study is looking at tissue samples from patients with T-cell acute lymphoblastic leukemia.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
49

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Dec 2006

Typical duration for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 28, 2006

Completed
2.4 years until next milestone

First Submitted

Initial submission to the registry

May 9, 2009

Completed
3 days until next milestone

First Posted

Study publicly available on registry

May 12, 2009

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 30, 2009

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 30, 2009

Completed
Last Updated

February 5, 2020

Status Verified

May 1, 2017

Enrollment Period

2.6 years

First QC Date

May 9, 2009

Last Update Submit

February 3, 2020

Conditions

Leukemia

Keywords

T-cell adult acute lymphoblastic leukemiaT-cell childhood acute lymphoblastic leukemiauntreated adult acute lymphoblastic leukemiauntreated childhood acute lymphoblastic leukemiarecurrent adult acute lymphoblastic leukemiarecurrent childhood acute lymphoblastic leukemiaadult acute lymphoblastic leukemia in remissionchildhood acute lymphoblastic leukemia in remission

Outcome Measures

Primary Outcomes (2)

  • Transcriptional signatures associated with NOTCH1 mutations in T-cell acute lymphoblastic leukemia (T-ALL) cells

    Mutational analysis

    1 month

  • Global changes on gene expression resulting from inactivation of NOTCH signaling in T-ALL cells

    Gene expression

    1 month

Interventions

microarray analysisGENETIC
mutation analysisGENETIC
immunologic techniqueOTHER

Eligibility Criteria

Age18 Years - 120 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Samples submitted for research from patients participating in E2993

You may not qualify if:

  • Not applicable

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Links

Biospecimen

Retention: SAMPLES WITH DNA

bone marrow and blood nucleic acids and cells.

MeSH Terms

Conditions

LeukemiaPrecursor Cell Lymphoblastic Leukemia-Lymphoma

Interventions

Microarray AnalysisImmunologic Techniques

Condition Hierarchy (Ancestors)

Neoplasms by Histologic TypeNeoplasmsHematologic DiseasesHemic and Lymphatic DiseasesLeukemia, LymphoidLymphoproliferative DisordersLymphatic DiseasesImmunoproliferative DisordersImmune System Diseases

Intervention Hierarchy (Ancestors)

Microchip Analytical ProceduresInvestigative Techniques

Study Officials

  • Adolfo A. Ferrando, MD, PhD

    Herbert Irving Comprehensive Cancer Center

    STUDY CHAIR

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
RETROSPECTIVE
Sponsor Type
NETWORK
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 9, 2009

First Posted

May 12, 2009

Study Start

December 28, 2006

Primary Completion

July 30, 2009

Study Completion

July 30, 2009

Last Updated

February 5, 2020

Record last verified: 2017-05