Lung Injury Prediction Study

NCT00889772 | Completed

• 2 other identifiers: 08-008726USCIITG-LIPS1
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of the study is to externally validate the acute lung injury/acute respiratory distress syndrome (ALI/ARDS) prediction model (Lung Injury Prediction Score - LIPS) in a multicenter sample of patients at risk presented to the acute care hospitals: United States Critical Illness and Injury Trials Group (USCIITG).

Conditions

Respiratory Distress; Acute Lung Injury

Keywords

Respiratory distress, adult; risk; emergency room; high risk surgery; sepsis; trauma; aspiration; pneumonia

Outcome Measures

Primary Outcomes (1)

• Acute Lung Injury or Acute Respiratory Distress Syndrome

  during hospital stay

Secondary Outcomes (1)

• Survival

  in hospital

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Consecutive patients \>18 years of age with one or more predisposing conditions for ALI/ARDS (pneumonia, sepsis, shock, pancreatitis, aspiration, high risk trauma and high risk surgery) at the time of hospital admission

You may qualify if:

• Hospitalized adult patients with one of the known risk factors for acute lung injury at the time of hospital admission

You may not qualify if:

• ALI/ARDS already present at the time of hospital admission, denied use of medical records for research, children, hospital readmission, transfer from another hospital

Sponsors & Collaborators

• Mayo Clinic: lead
• Icahn School of Medicine at Mount Sinai: collaborator
• Temple University: collaborator
• Johns Hopkins University: collaborator
• University of Medicine and Dentistry of New Jersey: collaborator
• University of Colorado, Denver: collaborator
• University of Pennsylvania: collaborator
• Brigham and Women's Hospital: collaborator
• Boston University: collaborator
• University of Michigan: collaborator
• University of Texas Southwestern Medical Center: collaborator
• Providence Health & Services: collaborator
• University of Illinois at Chicago: collaborator
• Wake Forest University: collaborator
• Bridgeport Hospital: collaborator
• Massachusetts General Hospital: collaborator
• Beth Israel Deaconess Medical Center: collaborator
• Wright State University: collaborator
• University of Missouri-Columbia: collaborator
• Uludag University: collaborator
• Akdeniz University: collaborator

Study Sites (1)

Mayo Clinic

Rochester, Minnesota, 55902, United States

Location

Related Publications (4)

• George N, Elie-Turenne MC, Seethala RR, Baslanti TO, Bozorgmehri S, Mark K, Meurer D, Bihorac A, Aisiku IP, Hou PC; U.S. Critical Illness and Injury Trials Group-Lung Injury Prevention Study Investigators. External Validation of the qSOFA Score in Emergency Department Patients With Pneumonia. J Emerg Med. 2019 Dec;57(6):755-764. doi: 10.1016/j.jemermed.2019.08.043. Epub 2019 Nov 15.

  PMID: 31735660 DERIVED

• Chang SY, Dabbagh O, Gajic O, Patrawalla A, Elie MC, Talmor DS, Malhotra A, Adesanya A, Anderson HL 3rd, Blum JM, Park PK, Gong MN; United States Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG-LIPS). Contemporary ventilator management in patients with and at risk of ALI/ARDS. Respir Care. 2013 Apr;58(4):578-88. doi: 10.4187/respcare.01755.

  PMID: 22906363 DERIVED

• Gajic O, Dabbagh O, Park PK, Adesanya A, Chang SY, Hou P, Anderson H 3rd, Hoth JJ, Mikkelsen ME, Gentile NT, Gong MN, Talmor D, Bajwa E, Watkins TR, Festic E, Yilmaz M, Iscimen R, Kaufman DA, Esper AM, Sadikot R, Douglas I, Sevransky J, Malinchoc M; U.S. Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG-LIPS). Early identification of patients at risk of acute lung injury: evaluation of lung injury prediction score in a multicenter cohort study. Am J Respir Crit Care Med. 2011 Feb 15;183(4):462-70. doi: 10.1164/rccm.201004-0549OC. Epub 2010 Aug 27.

  PMID: 20802164 DERIVED

• Trillo-Alvarez C, Cartin-Ceba R, Kor DJ, Kojicic M, Kashyap R, Thakur S, Thakur L, Herasevich V, Malinchoc M, Gajic O. Acute lung injury prediction score: derivation and validation in a population-based sample. Eur Respir J. 2011 Mar;37(3):604-9. doi: 10.1183/09031936.00036810. Epub 2010 Jun 18.

  PMID: 20562130 DERIVED

MeSH Terms

Conditions

Dyspnea; Acute Lung Injury; Emergencies; Sepsis; Wounds and Injuries; Pneumonia

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Lung Injury; Lung Diseases; Disease Attributes; Pathologic Processes; Infections; Systemic Inflammatory Response Syndrome; Inflammation; Respiratory Tract Infections

Study Officials

• Ognjen Gajic, M.D.

  Mayo Clinic

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Consultant - Critical Care

Study Record Dates

• First Submitted: April 27, 2009
• First Posted: April 29, 2009
• Study Start: March 1, 2009
• Primary Completion: February 1, 2010
• Study Completion: February 1, 2010
• Last Updated: September 24, 2015

Record last verified: 2012-06

Locations

US (1)