Hepatic Mitochondrial Function in Sepsis

NCT00889083 | Withdrawn

• 1 other identifier: IAAM-2009-1
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

Multi-organ failure due to sepsis is a major cause of death in critically ill patients. But the mechanisms leading to this condition are not fully understood. Mitochondrial dysfunction has been shown in skeletal muscle of critically ill septic patients. Liver is very important in sepsis as it is responsible of the synthesis of several inflammatory proteins. Moreover hepatic failure is associated to a bad outcome. The aim of this study is to evaluate the hepatic mitochondrial function in sepsis.

Conditions

Sepsis; Peritonitis

Keywords

Sepsis; Peritonitis; Mitochondria; Liver

Outcome Measures

Primary Outcomes (1)

• Mitochondrial complex activities

  during surgery

Secondary Outcomes (3)

• Quantification of adenine nucleotides

  during surgery

• Quantification of oxidative stress markers

  during surgery

• Correlation between SOFA score and mitochondrial complex activities

  28 days

Study Arms (2)

Control

Non septic patients needing hepatic surgery

Sepsis

Septic patients needing surgery for peritonitis

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Community sample

You may qualify if:

• Septic group : Peritonitis patients needing surgery
• Non septic group : Patients needing hepatic surgery

You may not qualify if:

• No liver biopsy performed

Sponsors & Collaborators

• Professor C ICHAI: lead

Study Sites (1)

CHU de Nice

Nice, 06003, France

Location

Related Publications (2)

• Brealey D, Brand M, Hargreaves I, Heales S, Land J, Smolenski R, Davies NA, Cooper CE, Singer M. Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet. 2002 Jul 20;360(9328):219-23. doi: 10.1016/S0140-6736(02)09459-X.

  PMID: 12133657 BACKGROUND

• Fredriksson K, Hammarqvist F, Strigard K, Hultenby K, Ljungqvist O, Wernerman J, Rooyackers O. Derangements in mitochondrial metabolism in intercostal and leg muscle of critically ill patients with sepsis-induced multiple organ failure. Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E1044-50. doi: 10.1152/ajpendo.00218.2006. Epub 2006 Jun 27.

  PMID: 16803854 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

Liver biopsies

MeSH Terms

Conditions

Sepsis; Peritonitis

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Intraabdominal Infections; Peritoneal Diseases; Digestive System Diseases

Study Officials

• Carole Ichai, MD, PhD

  Centre Hospitalier Universitaire de Nice

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor Chair of IAAM

Study Record Dates

• First Submitted: April 24, 2009
• First Posted: April 28, 2009
• Study Start: April 1, 2009
• Primary Completion: April 1, 2012
• Study Completion: April 1, 2012
• Last Updated: July 31, 2020

Record last verified: 2020-07

Locations

FR (1)