Reduction of Myocardial Infarction by Preconditioning in Patients With Ruptured Abdominal Aortic Aneurysm
PreconRAAA
1 other identifier
interventional
200
1 country
1
Brief Summary
Preconditioning in patients treated for elective abdominal aneurysm showed that the rate of perioperative myocardial infarction could be reduced by 80 %(ARR from 27% to 5%). Precondition where performed by 10 minutes of clamping of each iliac arteries before clamping the abdominal aorta. Human studies in cardiac patients have shown promising results with precondition. Instead of clamping arteries they have all performed the procedure by inflating a blood pressure cuff above arterial pressure on a arm. The investigators want to investigate if preconditioning induced by a blood pressure cuff on a arm can reduce the perioperative rate of myocardial infarction in patients open operated for ruptured abdominal aortic aneurysm.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Apr 2009
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2009
CompletedFirst Submitted
Initial submission to the registry
April 15, 2009
CompletedFirst Posted
Study publicly available on registry
April 17, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2014
CompletedJanuary 14, 2015
January 1, 2015
5.7 years
April 15, 2009
January 12, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Reduction in myocardial infarction
4 to 5 years
Secondary Outcomes (1)
Improvement in survival Description on inflammatory response
4 to 5 years
Study Arms (2)
Precondition
EXPERIMENTALInduction of precondition at start of operation on a arm
Control
NO INTERVENTIONNo precondition
Interventions
Precondition on a arm in four intervals at start of surgery for ruptured aortic aneurysm
Eligibility Criteria
You may qualify if:
- Patients with ruptured abdominal aortic aneurysm offered surgery
- Age \> 18 years
You may not qualify if:
- Technical inoperable
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Nikolaj Eldruplead
- Aarhus University Hospitalcollaborator
- Aarhus University Hospital Skejbycollaborator
Study Sites (1)
Aarhus university hospital skejby department of cardio thoracic and vascular surgery
Aarhus, Region Midt, 8200, Denmark
Related Publications (1)
Pedersen TF, Budtz-Lilly J, Petersen CN, Hyldgaard J, Schmidt JO, Kroijer R, Gronholdt ML, Eldrup N. Randomized clinical trial of remote ischaemic preconditioning versus no preconditioning in the prevention of perioperative myocardial infarction during open surgery for ruptured abdominal aortic aneurysm. BJS Open. 2018 Mar 26;2(3):112-118. doi: 10.1002/bjs5.55. eCollection 2018 Jun.
PMID: 29951634DERIVED
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Nikolaj Eldrup, MD PhD
Aarhus University Hospital Skejby
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- MD PhD
Study Record Dates
First Submitted
April 15, 2009
First Posted
April 17, 2009
Study Start
April 1, 2009
Primary Completion
December 1, 2014
Study Completion
December 1, 2014
Last Updated
January 14, 2015
Record last verified: 2015-01