NCT00880516

Brief Summary

The purpose of this study is to learn more about the genetics of chronic sinusitis and identify genes involved in chronic sinusitis.

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,200

participants targeted

Target at P75+ for all trials

Timeline
19mo left

Started Apr 2009

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress92%
Apr 2009Dec 2027

Study Start

First participant enrolled

April 1, 2009

Completed
8 days until next milestone

First Submitted

Initial submission to the registry

April 9, 2009

Completed
4 days until next milestone

First Posted

Study publicly available on registry

April 13, 2009

Completed
18.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2027

Last Updated

February 2, 2026

Status Verified

January 1, 2026

Enrollment Period

18.7 years

First QC Date

April 9, 2009

Last Update Submit

January 29, 2026

Conditions

Chronic Sinusitis

Outcome Measures

Primary Outcomes (1)

  • Association of genetic variation with CRS disease status

    Adult age

Study Arms (2)

control

Adults with normal sinuses

case

Adults with chronic sinusitis and positive findings on imaging.

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Adults with and without chronic sinusitis

You may qualify if:

  • Age\> 18 years
  • Diagnosis of chronic sinusitis or normal sinuses (with verification by imaging.) You must have a recent CT scan showing either normal sinuses or the presence of sinus disease.

You may not qualify if:

  • Genetic or acquired immunodeficiency
  • Ciliary dyskinesia
  • Cystic fibrosis
  • Autoimmune disease
  • Cancer of the sinuses

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Chicago

Chicago, Illinois, 60637, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

peripheral blood for DNA

Study Officials

  • Jayant Pinto, MD

    University of Chicago

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 9, 2009

First Posted

April 13, 2009

Study Start

April 1, 2009

Primary Completion (Estimated)

December 1, 2027

Study Completion (Estimated)

December 1, 2027

Last Updated

February 2, 2026

Record last verified: 2026-01

Locations

US(1)