NCT00874757|CompletedResultsFDA Drug
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Sponsor study identifier
observational
20
1 country
1
Study Start
November 15, 2010
Actual (reported)Primary Completion
September 1, 2011
Actual (reported)Study Completion
September 1, 2011
Actual (reported)The purpose of this study is to see whether Statin drugs will act as anti-inflammatories. The investigators will study this potential anti-inflammatory activity in healthy subjects.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
September 1, 2011
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 1, 2009
Actual (reported)April 2, 2009
Actual (reported)November 15, 2010
Actual (reported)September 1, 2011
Actual (reported)September 1, 2011
Actual (reported)August 23, 2024
Actual (reported)Toll-like Receptor 4 Expression Pre- and Post-Treatment
Toll-like Receptor 4 (TLR-4) expression on monocytes in whole blood pre- and post- 3 weeks of rosuvastatin treatment.
Before and after three weeks of treatment with rosuvastatin
Tumor Necrosis Factor (TNF)
Pre and post 3 weeks of rosuvastatin treatment
Interleukin-6
Before (baseline) and after 3 weeks of rosuvastatin treatment
Interleukin-8
measured in LPS treated blood before and after 3 weeks of Rosuvastatin treatment
Healthy subjects received rosuvastatin 20 mg orally for 3 weeks. Inflammatory markers measured pre and post rosuvastatin treatment.
Healthy subjects received rosuvastatin 20 mg orally for 3 weeks. Inflammatory markers measured pre- and post- rosuvastatin treatment.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
20 healthy subjects
University of Nebraska Medical Center, College of Pharmacy
Omaha, Nebraska, 68198-6045, United States
Wickelgren I. Immunology. Targeting the tolls. Science. 2006 Apr 14;312(5771):184-7. doi: 10.1126/science.312.5771.184. No abstract available.
Falagas ME, Makris GC, Matthaiou DK, Rafailidis PI. Statins for infection and sepsis: a systematic review of the clinical evidence. J Antimicrob Chemother. 2008 Apr;61(4):774-85. doi: 10.1093/jac/dkn019. Epub 2008 Feb 7.
Niessner A, Steiner S, Speidl WS, Pleiner J, Seidinger D, Maurer G, Goronzy JJ, Weyand CM, Kopp CW, Huber K, Wolzt M, Wojta J. Simvastatin suppresses endotoxin-induced upregulation of toll-like receptors 4 and 2 in vivo. Atherosclerosis. 2006 Dec;189(2):408-13. doi: 10.1016/j.atherosclerosis.2005.12.022. Epub 2006 Jan 26.
Timothy R McGuire, PharmD
University of Nebraska
20 participants (actual enrollment reported by the registry).
First Submitted
April 1, 2009
First Posted
April 2, 2009
Study Start
November 15, 2010
Actual (reported)A Drug Drug Interaction (DDI) Study of Selpercatinib (LY3527723) and Rosuvastatin in Healthy Participants
Contact the study team to confirm eligibility.
Novack V, Eisinger M, Frenkel A, Terblanche M, Adhikari NK, Douvdevani A, Amichay D, Almog Y. The effects of statin therapy on inflammatory cytokines in patients with bacterial infections: a randomized double-blind placebo controlled clinical trial. Intensive Care Med. 2009 Jul;35(7):1255-60. doi: 10.1007/s00134-009-1429-0. Epub 2009 Feb 11.
Wang CY, Liu PY, Liao JK. Pleiotropic effects of statin therapy: molecular mechanisms and clinical results. Trends Mol Med. 2008 Jan;14(1):37-44. doi: 10.1016/j.molmed.2007.11.004.
Primary Completion
September 1, 2011
Actual (reported)Study Completion
September 1, 2011
Actual (reported)Last Updated
August 23, 2024
Results First Posted
August 23, 2024
Record last verified: 2024-03
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
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