Examining Long-Term Effects and Neural Mediators of Behavioral Treatments for Social Anxiety Disorder
Neural Mediators of Behavior Therapy for Anxiety
2 other identifiers
interventional
50
1 country
1
Brief Summary
This study will compare the effects that two types of behavioral therapy have on brain function in people with social anxiety disorder.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Oct 2008
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2008
CompletedFirst Submitted
Initial submission to the registry
March 30, 2009
CompletedFirst Posted
Study publicly available on registry
March 31, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2013
CompletedDecember 11, 2014
December 1, 2014
4.9 years
March 30, 2009
December 9, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Brain activity, assessed using functional magnetic resonance imaging (fMRI)
Measured at baseline and after 3 and 12 months
Secondary Outcomes (1)
Social anxiety symptoms
Measured at baseline and after 3, 6, and 12 months
Study Arms (3)
1
ACTIVE COMPARATORParticipants will receive standard cognitive behavioral therapy.
2
EXPERIMENTALParticipants will receive acceptance- and commitment-based behavioral therapy.
3
NO INTERVENTIONParticipants will be placed on a waitlist for 3 months before being offered treatment.
Interventions
12 weekly treatment sessions conducted individually with a therapist; strategies for dealing with anxiety will include mindfulness and acceptance of negative feelings
12 weekly treatment sessions conducted individually with a therapist; methods for dealing with anxiety will include cognitive and breathing strategies
Eligibility Criteria
You may qualify if:
- Meets diagnostic criteria for social anxiety disorder
- Right-handed
- If taking medications, stabilized on current dose for 3 months
- If undergoing psychotherapy, stabilized for 6 months
- Speaks English
You may not qualify if:
- Currently undergoing cognitive behavioral therapy
- History of psychiatric hospitalization in the last 5 years
- Presence of serious medical condition, such as respiratory, cardiovascular, pulmonary, neurological, or muscular-skeletal disease or pregnancy
- Active suicidal ideation
- Current severe depression
- History of bipolar disorder, psychosis, mental retardation, or brain damage
- History of substance abuse or dependence in the last 6 months
- Presence of irremovable metal objects in the body that are not fMRI-safe
- Suffers from claustrophobia
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
UCLA Psychology Department - Franz Hall
Los Angeles, California, 90095, United States
Related Publications (1)
Niles AN, Burklund LJ, Arch JJ, Lieberman MD, Saxbe D, Craske MG. Cognitive mediators of treatment for social anxiety disorder: comparing acceptance and commitment therapy and cognitive-behavioral therapy. Behav Ther. 2014 Sep;45(5):664-77. doi: 10.1016/j.beth.2014.04.006. Epub 2014 May 5.
PMID: 25022777DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Michelle G. Craske, PhD
University of California, Los Angeles
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- PhD
Study Record Dates
First Submitted
March 30, 2009
First Posted
March 31, 2009
Study Start
October 1, 2008
Primary Completion
September 1, 2013
Study Completion
September 1, 2013
Last Updated
December 11, 2014
Record last verified: 2014-12