Pregnancy-Induced Analgesia - A Longitudinal Study of DNIC
1 other identifier
observational
60
1 country
2
Brief Summary
The investigators hypothesize that pregnancy-induced analgesia might be the result of enhanced descending noxious inhibitory activity.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Mar 2009
Longer than P75 for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2009
CompletedFirst Submitted
Initial submission to the registry
March 20, 2009
CompletedFirst Posted
Study publicly available on registry
March 24, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2013
CompletedJune 19, 2013
June 1, 2013
4.8 years
March 20, 2009
June 17, 2013
Conditions
Outcome Measures
Primary Outcomes (1)
To use psychophysical tests to study both the inhibitory and excitatory pain pathways using the DNIC paradigm and temporal summation longitudinally during pregnancy, compared to an age-matched control group of non-pregnant women.
Pregnant Cohort - each trimester and postpartum; Control Cohort - twice a menstrual cycle, 4 cycles, over 7 months
Secondary Outcomes (1)
Questionnaires, pain scores, amount of analgesics required, overall experience of labor and delivery
Questionnaires - Same as Primary Outcome Measure; other three measures - at delivery
Study Arms (3)
1. Pregnant Women
2. Non-Pregnant Controls
3. IVF controls
Eligibility Criteria
maternity clinic - Pregnant Cohort community sample - Non-pregnant Control Cohort
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Washingtonlead
- Stanford Universitycollaborator
Study Sites (2)
Stanford University School of Medicine
Stanford, California, 94305, United States
University of Washington
Seattle, Washington, 98195-6540, United States
Study Officials
- PRINCIPAL INVESTIGATOR
Ruth Landau, MD
University of Washington
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
March 20, 2009
First Posted
March 24, 2009
Study Start
March 1, 2009
Primary Completion
December 1, 2013
Study Completion
December 1, 2013
Last Updated
June 19, 2013
Record last verified: 2013-06