NCT00866801|Completed
Coronary Blood Flow Regulation During General Anesthesia
Cardiac Sympathetic Innervation and Coronary Blood Flow Regulation During General Anesthesia
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Cardiac Sympathetic Innervation and Coronary Blood Flow Regulation During General Anesthesia
Sponsor study identifier
Secondary identifiers
observational
45
1 country
1
Study Start
April 2009
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
February 2014
Actual (reported)Study Completion
October 2014
Actual (reported)The central hypothesis in the present project is that general anesthesia may alter autonomic control such that perioperative coronary blood flow (CBF) is significantly disturbed. These disturbances in coronary blood flow may contribute to the development of myocardial ischemia in the perioperative period. Furthermore, patients with an intrinsically altered autonomic sympathetic innervation, like diabetics, are even more prone to develop perioperative disturbances in coronary blood flow. Here the researchers will investigate what the direct effects are of general and locoregional anesthesia on the CBF. Furthermore, the researchers aim to evaluate whether diabetic subjects show more disturbed CBF responses to anesthesia as compared to non-diabetics.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
October 2014
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 20, 2009
Actual (reported)March 23, 2009
Actual (reported)April 2009
Date type not reportedThis date has not been verified as actual or estimated.
February 2014
Actual (reported)October 2014
Actual (reported)Coronary flow reserve
Within the first 3 days postoperatively
Diabetic autonomic neuropathy
Within the first 3 days postoperatively
Healthy subjects scheduled for general anesthesia
Healthy subjects scheduled for general anesthesia and thoracic epidural analgesia
Subjects with diabetes scheduled for general anesthesia
Subjects with diabetes and cardiovascular autonomic neuropathy scheduled for general anesthesia
The study population consists patients scheduled for surgery and general anesthesia. Patients will be recruited from the preoperative screening clinic in the four, aforementioned, groups of patients.
VU University Medical Center
Amsterdam, North Holland, 1007 MB, Netherlands
Bulte CS, van den Brom CE, Loer SA, Boer C, Bouwman RA. Myocardial blood flow under general anaesthesia with sevoflurane in type 2 diabetic patients: a pilot study. Cardiovasc Diabetol. 2014 Mar 23;13:62. doi: 10.1186/1475-2840-13-62.
Frozen plasma will be retained
Carolien SE Bulte, MD
Amsterdam UMC, location VUmc
R. A. Bouwman, MD, PhD
Amsterdam UMC, location VUmc
C. Boer, PhD
Amsterdam UMC, location VUmc
S. A. Loer, MD, PhD, MSC
Amsterdam UMC, location VUmc
45 participants (actual enrollment reported by the registry).
First Submitted
March 20, 2009
First Posted
March 23, 2009
Study Start
April 2009
Date type not reportedThis date has not been verified as actual or estimated.
Contact the study team to confirm eligibility.
O. Kamp, MD, PhD
Amsterdam UMC, location VUmc
M. Diamant, MD, PhD
Amsterdam UMC, location VUmc
Primary Completion
February 2014
Actual (reported)Study Completion
October 2014
Actual (reported)Last Updated
October 14, 2015
Record last verified: 2015-10
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Source: ClinicalTrials.gov.
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