Pepsin As A Biomarker For Aspiration
Pepsin as a Biomarker for Aspiration Due to Gastroesophageal Reflux
2 other identifiers
observational
76
1 country
1
Brief Summary
Evaluation of tracheal pepsin as a biomarker for aspiration
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Feb 2008
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2008
CompletedFirst Submitted
Initial submission to the registry
March 19, 2009
CompletedFirst Posted
Study publicly available on registry
March 20, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2012
CompletedOctober 23, 2013
October 1, 2013
4.8 years
March 19, 2009
October 22, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
pepsin concentration
1 day
Study Arms (3)
1
patients undergoing elective procedures with intubation and no known respiratory pathology
2
patients with tracheostomy
3
patients with chronic lung disease or respiratory symptoms undergoing bronchoscopy
Interventions
Tracheal Lavage will be performed on the control population patients and the tracheal fluid obtained from this procedure will be used as the research sample.
Eligibility Criteria
Normal children undergoing general endotracheal anesthesia Children with tracheostomies Children undergoing bronchoscopy Intubated children in PICU
You may qualify if:
- Meet criteria of study population
You may not qualify if:
- Lack of informed consent/assent
- Pulmonary disease in normal controls
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Children's Hospital of Wisconsin
Milwaukee, Wisconsin, 53226, United States
Biospecimen
Tracheal fluid
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Nikki Johnston, PhD
Medical College of Wisconsin
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
March 19, 2009
First Posted
March 20, 2009
Study Start
February 1, 2008
Primary Completion
December 1, 2012
Study Completion
December 1, 2012
Last Updated
October 23, 2013
Record last verified: 2013-10