Regulation of Vascular Thrombosis in Sleep Apnea

NCT00859690 | Completed

• 2 other identifiers: 0901010175Robert Wood Johnson Foundation
• Study Type: observational
• Target: 14
• Locations: 0 countries
• Sites: N/A

Brief Summary

Sleep Apnea is a prevalent condition that has been increasingly diagnosed in the adult population and is now considered an independent risk factor for the development of cardiovascular disease. A better understanding of the mechanisms associated with the development of cardiovascular disease in sleep apnea is needed. This research will investigate the function of the adenosine deaminase (ADA) in subjects with sleep disorders. This enzyme is responsible for metabolizing adenosine, a neuromodulator that is released during periods of sleep apnea and that has been found to promote vascular thrombosis. There are multiple types of ADA that are genetically determined and have different levels of function. Those different forms of this enzyme may determine groups that are more susceptible to the development of thrombosis. Given the known association between sleep apnea and thrombosis, this study will determine if polymorphisms of this enzyme are differentially found in subjects with sleep apnea as compared to other sleep disturbances. The overall objective of this experiment is to assess the presence of ADA polymorphisms in sleep apnea.

Conditions

Obstructive Sleep Apnea

Keywords

Obstructive Sleep Apnea; Thrombosis; Adenosine Deaminase; Sleep Disorder

Outcome Measures

Primary Outcomes (1)

• ADA gene sequence

  Determined after outpatient blood draw

Study Arms (2)

Sleep Disorder - Sleep Apnea

Subjects determined by a clinically indicated overnight sleep study (Nocturnal Polysomnography) to have Obstructive Sleep Apnea (OSA).

Sleep Disorder - Not Sleep Apnea

Subjects determined by a clinically indicated overnight sleep study (Nocturnal Polysomnography) to have a sleep disorder other than Obstructive Sleep Apnea (OSA).

Eligibility Criteria

• Age: 21 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Subjects will be recruited from patients presenting for sleep disorders at the Weill Cornell Pulmonary Associates / Cornell Center for Sleep Medicine practices at New York-Presbyterian Hospital in New York City.

You may qualify if:

• years or older
• Patient of the Weill Cornell Pulmonary Associates and Cornell Center for Sleep Medicine practices
• Clinically indicated for an overnight sleep study within six months prior to or after the outpatient office visit

You may not qualify if:

• Pregnancy

Sponsors & Collaborators

• Weill Medical College of Cornell University: lead
• Robert Wood Johnson Foundation: collaborator

Biospecimen

Retention: SAMPLES WITH DNA

A total of 15ml (approximately 1 tablespoon) of whole blood will be collected from each subject during his or her out-patient office visit. This sample will be retained for genomic analysis

MeSH Terms

Conditions

Sleep Apnea, Obstructive; Thrombosis; Sleep Wake Disorders

Condition Hierarchy (Ancestors)

Sleep Apnea Syndromes; Apnea; Respiration Disorders; Respiratory Tract Diseases; Sleep Disorders, Intrinsic; Dyssomnias; Nervous System Diseases; Embolism and Thrombosis; Vascular Diseases; Cardiovascular Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Mental Disorders

Study Officials

• Ana C Krieger, MD, MPH

  Weill Medical College of Cornell University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 10, 2009
• First Posted: March 11, 2009
• Study Start: March 1, 2009
• Primary Completion: July 1, 2013
• Study Completion: July 1, 2013
• Last Updated: January 18, 2019

Record last verified: 2019-01