Neurosciences Research Repository

NCT00857922 | Recruiting DMC

• 1 other identifier: HSC-MS-08-0413
• Study Type: observational
• Target: 15,000
• Locations: 1 country
• Sites: 1

Brief Summary

In order to expand neuroscience research and move laboratory advances to patients, there is a need to integrate reliable clinical data with biologic information from patient tissue specimens. The Neuroscience Research Repository (NRR) seeks to meet this need. The NRR is a prospective database and sample bank created to collect information and samples for current and future neuroscience research. The objective of this NRR is to develop a data and sample repository for study of neurological conditions. A repository utilizing standardized electronic health data and samples collected in a uniform manner serves to foster the ability to perform research on current and future projects. Samples and data for clinical, genomic and proteomic analysis will be provided to optimize their value for neuroscience research. The NRR will enroll patients and collect clinically recorded longitudinal data for as long as they are followed by the Neurosurgery service and up to an additional 5 years after being released from care. Patients will be enrolled on admission to the service and samples will be taken at three time points: Time One, within 24 hours of event (preferably first blood draw); Time Two, within 48 hours of event; and Time Three, time of any residual tissue availability. Family members of select groups of patients will also be approached for enrollment. Samples and data will be labeled with a study code to maintain confidentiality. Samples and data will be maintained in secure, limited access environments with back-up/redundancy procedures in place. Sample inventory will be maintained with a bar-coding system. A duty to warn clause will be included in the consent as will the determination of willingness to be re-contacted for future research. Time of sample acquisition to time of sample processing will be documented for quality control purposes. Freezers will be monitored for temperature stability. Recipient investigators will be requested to provide feedback on sample quality. Samples will be distributed to neuroscience investigators after approval from the Neurosurgery Scientific Review Committee - Dissemination Review Committee and the Committee for the Protection of Human Subjects (CPHS).

Conditions

Neurological Conditions

Keywords

Neurological; Neurosurgical

Outcome Measures

Primary Outcomes (1)

• Discharge status

  Standardized functional outcome score

  hospital discharge

Study Arms (2)

Neurosurgical patient

Neurosurgical patient of the Mischer Neuroscience Institute, 18 years and over

Other: tissue and data repository

Family members

Family members of specific vascular, trauma, brain tumor and functional disorder cohorts

Other: tissue and data repository

Interventions

tissue and data repository OTHER

Tissue and data will be maintained in a repository for study from consenting subjects.

Family members; Neurosurgical patient

Eligibility Criteria

• Age: 0 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients admitted to the Neurosurgery service (Mischer Neuroscience Institute/UT Department of Neurosurgery or Neurosurgical Critical Care service) are eligible for this study. Family members of those with select conditions will be approached for enrollment at a future date.

You may qualify if:

• Neurosurgical patient (primary or consulting); patients\<18 includes residual tissue only, no blood samples.
• Family members of specific vascular, trauma, brain tumor and functional disorder cohorts (will be identified in future addendums to this repository)

You may not qualify if:

• \. Inability to obtain informed consent

Sponsors & Collaborators

• The University of Texas Health Science Center, Houston: lead

Study Sites (1)

Memorial Hermann Hospital

Houston, Texas, 77030, United States

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

whole blood, plasma, white cells, saliva, tissue, CSF

MeSH Terms

Conditions

Neurologic Manifestations

Interventions

Histocompatibility Testing

Condition Hierarchy (Ancestors)

Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Immunologic Tests; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques; Immunologic Techniques

Study Officials

• Georgene W Hergenroeder, PhD

  McGovern Medical School at UTHealth

  PRINCIPAL INVESTIGATOR

Central Study Contacts

G Hergenroeder

CONTACT

Georgene.W.Hergenroeder@uth.tmc.edu

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Study Director, PI, Associate Professor

Study Record Dates

• First Submitted: March 6, 2009
• First Posted: March 9, 2009
• Study Start: March 1, 2009
• Primary Completion (Estimated): March 1, 2030
• Study Completion (Estimated): August 1, 2030
• Last Updated: August 7, 2025

Record last verified: 2025-08

Locations

US (1)