Affective Processing in Depression and Epilepsy

NCT00855725 | Terminated

• 2 other identifiers: GCRC 024608-128
• Study Type: observational
• Target: 14
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this study is to determine whether there are unique markers on neuroimaging that are associated with depression in epilepsy.

Conditions

Epilepsy; Depression; Healthy

Keywords

Epilepsy; Depression; Neurology; fMRI; Healthy Controls

Interventions

fMRI OTHER

Subjects will undergo MRI scanning to gather data about cognetive functions.

Hamilton Depression Rating Scale OTHER

Investigator will evalute the subject during a one on one interview for depression using the Hamilton Depression Rating Scale.

Beck's Depressive Inventory OTHER

Subjects will complete self assessment to evaluate their level of depression.

Interictal Dysphoric Disorder Inventory (IDDI) OTHER

Subject will complete self assessment to determine if there have been any changes in mood, emotions and or feelings from time to time.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

There are four study groups. 1. Healthy Controls 2. Subjects with epilepsy only 3. Subjects with primary depression only 4. Subjects with epilepsy and depressive symptoms.

You may qualify if:

• Healthy adults of 18 years of age or older.

You may not qualify if:

• Subject has no history of affective disorders
• Subject scores higher than 5 on Hamilton Depression Rating Scale
• Subject with prior primary diagnosis of any psychotic disorder, bipolar disorder, anxiety disorder, or any other serious medical or neurological disorder
• Subject is pregnant
• Subject is unable to undergo a MRI
• Epilepsy Only Group
• Subject is at least 18 years of age
• Subject has confirmed temporal lobe epilepsy (TLE)
• Subject has a history of depression
• Subject scores higher then 5 on Hamilton Depression Rating Scale
• Subject with prior primary diagnosis of any psychotic disorder, bipolar disorder, anxiety disorder, or any other serious medical or neurological disorder
• Subject is pregnant
• Subject is unable to undergo a MRI
• Depression Only Group
• Subject is at least 18 years of age

Sponsors & Collaborators

• Northwell Health: lead

Study Sites (1)

North Shore LIJ Health System

Manhasset, New York, 11030, United States

Location

MeSH Terms

Conditions

Epilepsy; Depression

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Behavioral Symptoms; Behavior

Study Officials

• Alan Ettinger, M.D.

  Northwell Health

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: March 3, 2009
• First Posted: March 4, 2009
• Study Start: June 1, 2008
• Primary Completion: June 1, 2009
• Study Completion: June 1, 2009
• Last Updated: July 9, 2009

Record last verified: 2009-07

Locations

US (1)