Muscle Strength and Exercise Capacity in Sarcoidosis Patients

NCT00854672 | Completed DMC

• 1 other identifier: MEC 09-4-007
• Study Type: observational
• Target: 124
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to examine exercise capacity, muscle strength and fatigue in sarcoidosis. In this longitudinal study the changes in prevalence of exercise intolerance, reduced muscle strength and fatigue will be established in a two-year follow-up. Also the relation between these physical impairments in time and other clinical parameters, such as QOL, will be established.

Conditions

Sarcoidosis

Keywords

Sarcoidosis; muscle strength; exercise intolerance; QOL

Outcome Measures

Primary Outcomes (1)

• Exercise capacity, muscle strength and fatigue in sarcoidosis: a two-year follow-up study

  6MWD and muscle strength measurements of arm (isometric strength of the elbow flexors) and leg (isokinetic peak torques of the hamstrings and quadriceps) muscles. Questionnaires: WHOQOL-bref and Fatigue Assessment Scale (FAS).

  30 months

Study Arms (1)

sarcoidosis patients

Sarcoidosis patients referred to the ild care team of the outpatient clinic of the department of Respiratory Medicine of the MUMC and also participated in the baseline study between November 2008 and September 2009 will be included in this study

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Sarcoidosis patients referred to the ild care team of the outpatient clinic of the department of Respiratory Medicine of the Maastricht University Medical Centre (MUMC) a tertiary referral center in the Netherlands will be included in this study

You may qualify if:

• diagnosed sarcoidosis according to WASOG/ATS/ERS guidelines

You may not qualify if:

• not being able to walk

Sponsors & Collaborators

• Maastricht University Medical Center: lead
• ild care foundation: collaborator

Study Sites (1)

Maastricht University Medical Center

Maastricht, Netherlands

Location

Related Publications (2)

• Marcellis RG, Lenssen AF, Elfferich MD, De Vries J, Kassim S, Foerster K, Drent M. Exercise capacity, muscle strength and fatigue in sarcoidosis. Eur Respir J. 2011 Sep;38(3):628-34. doi: 10.1183/09031936.00117710. Epub 2011 Mar 24.

  PMID: 21436356 RESULT

• Marcellis RG, Lenssen AF, Kleynen S, De Vries J, Drent M. Exercise capacity, muscle strength, and fatigue in sarcoidosis: a follow-up study. Lung. 2013 Jun;191(3):247-56. doi: 10.1007/s00408-013-9456-6. Epub 2013 Apr 5.

  PMID: 23558599 DERIVED

Related Links

• official site of ild care foundation which facilitates research on patients with interstitial lung disease
• official site of the Maastricht University Medical Centre

MeSH Terms

Conditions

Sarcoidosis

Condition Hierarchy (Ancestors)

Lymphoproliferative Disorders; Lymphatic Diseases; Hemic and Lymphatic Diseases; Hypersensitivity, Delayed; Hypersensitivity; Immune System Diseases

Study Officials

• Rik Marcellis, MSc

  Maastricht University Medical Center

  PRINCIPAL INVESTIGATOR

• Marjolein Drent, MD, PhD

  Maastricht University Medical Center and University Maastricht

  STUDY CHAIR

• Ton Lenssen, MSc, PhD

  Maastricht UMC and University of Maastricht

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. Marjolein Drent

Study Record Dates

• First Submitted: February 26, 2009
• First Posted: March 3, 2009
• Study Start: January 1, 2009
• Primary Completion: August 1, 2009
• Study Completion: September 1, 2011
• Last Updated: April 6, 2012

Record last verified: 2012-04

Locations

NL (1)