Examining the Role of Vitamin D in Asthma and Chronic Obstructive Pulmonary Disease (COPD)

NCT00851695 | Completed

• 2 other identifiers: 1399R21HL089842-01
• Study Type: observational
• Target: 2,266
• Locations: 0 countries
• Sites: N/A

Brief Summary

Asthma and chronic obstructive pulmonary disease (COPD) are diseases that affect a person's ability to breathe normally. People who do not receive enough vitamin D may have a higher risk of developing asthma or COPD. This study will examine previously collected blood samples of participants in three studies to determine whether people with low vitamin D levels have an increased risk of severe asthma or COPD.

Conditions

Asthma; Pulmonary Disease; Chronic Obstructive

Keywords

Lung Function Decline; Lung Function; Allergy; COPD; Vitamin D

Outcome Measures

Primary Outcomes (2)

• Asthma exacerbation

  Measured at Year 4 in the original study

• Lung function decline

  Measured at Year 15 in the original study

Secondary Outcomes (1)

• Allergy markers

  Measured at Year 4 in the original study

Study Arms (3)

Asthma

All 1024 participants of the Childhood Asthma Management Program, who provided blood samples.

Asthma in Hispanics

All 616 subjects in the Genetic Epidemiology of Asthma in Costa Rica who have serum.

Lung function and lung function decline

626 subjects from the Normative Aging Study who have serum and lung function.

Eligibility Criteria

• Age: 5 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

For the Childhood Asthma Management Program, the study population was children with mild to moderate asthma, 5 to 12 years of age, living across the United States. For the Genetic Epidemiology of Asthma in Costa Rica study, the study population was children with asthma, 5 to 12 years of age, living in Costa Rica. For the Normative Aging Study, the study population was a community sample of men living in the Boston area.

You may qualify if:

• Participated in the Childhood Asthma Management Program, the Genetic Epidemiology of Asthma in Costa Rica study, or the Normative Aging Study

Sponsors & Collaborators

• Brigham and Women's Hospital: lead
• National Heart, Lung, and Blood Institute (NHLBI): collaborator

Biospecimen

Retention: SAMPLES WITH DNA

Serum samples

MeSH Terms

Conditions

Asthma; Lung Diseases; Hypersensitivity; Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Immune System Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Augusto A. Litonjua, MD, MPH

  Brigham and Women's Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: February 20, 2009
• First Posted: February 26, 2009
• Study Start: July 1, 2007
• Primary Completion: June 1, 2010
• Study Completion: June 1, 2010
• Last Updated: August 13, 2012

Record last verified: 2012-08