Genetic Basis of Idiopathic Focal Epilepsies With Cognitif Deficits
1 other identifier
interventional
N/A
1 country
4
Brief Summary
Epilepsy is a frequent neurological disease in childhood, characterized by recurrent seizures and sometimes with major effects on social, behavioral and cognitive development. Childhood focal epilepsies particularly are age-related diseases mainly occurring during developmental critical period. A complex interplay between brain development and maturation processes and susceptibility genes may contribute to the development of various childhood epileptic syndromes associated with language and cognitive deficits. Indeed, the Landau-Kleffner syndrome (LKS), the continuous spike-and-waves during sleep syndrome (CSWS), and the benign childhood epilepsy with centrotemporal spikes (BCECTS) or benign rolandic epilepsy, are different syndromes that are considered as part of a single continuous spectrum of disorders. While genetic component in those three syndromes remains elusive, novel and high throughput genome analyzes could bring interesting insights into the possible genetic defects and pathophysiological mechanisms underlying and linking the various disorders associating epilepsy with speech and cognitive impairments.
Trial Health
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4 active sites
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Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 24, 2009
CompletedFirst Posted
Study publicly available on registry
February 25, 2009
CompletedFebruary 25, 2009
February 1, 2009
February 24, 2009
February 24, 2009
Conditions
Keywords
Interventions
Eligibility Criteria
You may qualify if:
- iodiopathic focal epilepsy with cognitif deficit
You may not qualify if:
- medical history of status epilepticus
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (4)
Hôpital Femme Mère Enfant - Hospices Civils de Lyon, Service Epilepsie, Sommeil et Exploration fonctionnelle neurologique pédiatrique
Bron, 69500, France
American Memorial Hospital, CHU de Reims, Unité de Neurologie Pédiatrique - Service Pédiatrie A
Reims, 51092, France
Clinique neurologique, Hôpitaux Universitaires de Strasbourg
Strasbourg, 67091, France
Hôpital de Hautepierre, Service de pédiatrie 1
Strasbourg, 67098, France
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Edouard HIRSCH, MD
University Hospital, Strasbourg, France
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
February 24, 2009
First Posted
February 25, 2009
Last Updated
February 25, 2009
Record last verified: 2009-02