Study Stopped
Difficulty with recruiting willing participants.
Comparing the Effects of Two Beta Blockers,Metoprolol and Nebivolol,on Ambulatory Blood Pressure and Basal Metabolic Rate
Comparative Effects of Nebivolol Versus Metoprolol on 24-hour Blood Pressures and Basal Metabolic Rate: An Open-Label Study
1 other identifier
interventional
1
1 country
1
Brief Summary
The purpose of the study is to compare the effects of nebivolol and metoprolol on 24-hour ambulatory blood pressure characteristics and basal metabolic rates in patients with hypertension.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable hypertension
Started Jan 2009
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2009
CompletedFirst Submitted
Initial submission to the registry
February 2, 2009
CompletedFirst Posted
Study publicly available on registry
February 24, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2010
CompletedResults Posted
Study results publicly available
March 19, 2013
CompletedMarch 19, 2013
March 1, 2013
1.8 years
February 2, 2009
March 18, 2013
March 18, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Primary Outcome is Pre- and Post-treatment Ambulatory Blood Pressure.
4 weeks (pre- and post-treatment)
Study Arms (1)
Metoprolol to nebivolol
EXPERIMENTALmetoprolol 25-200mg at a stable daily dose for 4 weeks, then change to nebivolol at a comparable stable dose (5-20 mg) for 4 -5 weeks.
Interventions
Metoprolol tablets 25-200 mg daily times four weeks. Nebivolol daily for 4-5 weeks
Eligibility Criteria
You may qualify if:
- years old or older
- currently be treated at a University of MS Medical Center Internal Medicine Clinics
- currently taking metoprolol succinate for hypertension
- have their hypertension controlled (\<140/90).
You may not qualify if:
- uncontrolled hypertension
- severe renal or moderate hepatic impairment
- currently taking CYP 2D6 inducers/inhibitors
- recent stroke (less than 6 months)
- recent myocardial infarction (less than 6 months)
- congestive heart failure
- diagnosed obstructive sleep apnea
- atrial fibrillation
- arm circumference \>50 cm
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Mississippi Medical Center
Jackson, Mississippi, 39216, United States
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Professor of Medicine
- Organization
- University of Mississippi Medical Center
Study Officials
- PRINCIPAL INVESTIGATOR
Deborah Minor, PharmD
University of Mississippi Medical Center
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor of Medicine
Study Record Dates
First Submitted
February 2, 2009
First Posted
February 24, 2009
Study Start
January 1, 2009
Primary Completion
November 1, 2010
Study Completion
November 1, 2010
Last Updated
March 19, 2013
Results First Posted
March 19, 2013
Record last verified: 2013-03