NCT00846339

Brief Summary

Bupropion has different effects on D2 dopamine receptors according to genotype.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
12

participants targeted

Target at below P25 for phase_4

Timeline
Completed

Started Nov 2008

Shorter than P25 for phase_4

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2008

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

February 14, 2009

Completed
4 days until next milestone

First Posted

Study publicly available on registry

February 18, 2009

Completed
11 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2009

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2009

Completed
Last Updated

February 23, 2011

Status Verified

February 1, 2011

Enrollment Period

4 months

First QC Date

February 14, 2009

Last Update Submit

February 19, 2011

Conditions

Smoking

Keywords

Smoking cessationBupropion

Outcome Measures

Primary Outcomes (1)

  • Dopamine receptor occupancy

    1 week

Secondary Outcomes (1)

  • Pharmacokinetic parameters of bupropion and hydroxybupropion

    1 week

Study Arms (2)

1

EXPERIMENTAL

DRD2 Taq1A1 allele

Drug: Bupropion

2

EXPERIMENTAL

DRD Taq1 A2 homozygote2

Drug: Bupropion

Interventions

BupropionDRUG

bupropion

12

Eligibility Criteria

Age20 Years - 50 Years
Sexmale
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Active smoker (more than 10 cigarettes per day for the past 2 years)

You may not qualify if:

  • Medical or psychiatric co-morbidity
  • Hypersensitive to bupropion

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Seoul National University Hospital

Seoul, 110-744, South Korea

Location

MeSH Terms

Conditions

SmokingSmoking Cessation

Interventions

Bupropion

Condition Hierarchy (Ancestors)

BehaviorHealth Behavior

Intervention Hierarchy (Ancestors)

PropiophenonesKetonesOrganic Chemicals

Study Officials

  • Kyung-Sang Yu, MD

    Seoul National Univeristy Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 4
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

February 14, 2009

First Posted

February 18, 2009

Study Start

November 1, 2008

Primary Completion

March 1, 2009

Study Completion

June 1, 2009

Last Updated

February 23, 2011

Record last verified: 2011-02

Locations

KR(1)